IndraLab

Statements

TLR4 binds IL1B. 12 / 14
| 8 4
sparser
"Among soluble inflammatory mediators, the danger signal molecule high-mobility group box-1 (HMGB-1) also plays a central role in neuroinflammation, being involved in the TLR4-IL-1β axis, and in the enhancement of the CNS inflammatory response (25) ."
35359659
sparser
"The anti-tumor immune signaling pathway is inhibited when receptor TLR4 is bound by the IL1B ligand in the microenvironment."
35164166
reach
"The gram negative bacterial cell wall component LPS and IL-1beta, which bind to Toll Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
sparser
"The gram-negative bacterial cell wall component LPS and IL-1β, which bind to Toll-Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
reach
"Our results also propose that IL-1beta may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
reach
"6 Binding of IL-1beta to IL-1R or LPS to TLR4 causes recruitment of adopter proteins such as MyD88, IRAK, and TRAF6 to the receptor."
22833096
sparser
"Our results also propose that IL-1β may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
reach
"MA at ST36, Guanyuan (CV4), and Yongquan (KI1) inhibits the recruitment and activation of hepatic macrophages via the TLR4/MyD88 and NF-κB pathways and the expression of IL-1β and TNF-α downstream, thereby improving related symptoms."
34992414
reach
"These findings extended the above mentioned studies in demonstrating that RLX could ameliorate NLRP3 inflammasome activity in myofibroblasts to inhibit the pro fibrotic interaction between TGF-beta1, TLR-4 and IL-1beta and IL-18 (XREF_FIG) on myofibroblast differentiation and myofibroblast induced interstitial collagen deposition."
32848798
reach
"The association between precancerous gastric lesions and serum pepsinogens, serum gastrin, vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status."
23137754
reach
"The four SNPs that had significant single SNP associations with either IL-1alpha (IL-1RAP rs6444435) or IL-1beta (IL-1R2 - rs4851527 and rs4851531, IL-1RAP - rs6765375) in AA were tested for interaction effects with the two SNPs in TLR4 (rs1554973 and rs7856729) that were associated with IL-1alpha and IL-1beta in European Americans in a previous study."
21704385
reach
"The aim of this study was to investigate the association between serum pepsinogens, serum gastrin, serum vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status in patients with various gastric precancerous lesions."
23137754