IndraLab

Statements

TLR4 binds IL1B. 17 / 19
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"Our results also propose that IL-1beta may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
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"LPS which is a component of the cell wall of Gram-negative bacteria as well as IL-1β bind to TLR4 and IL 1-RA respectively and play an important role in this area."
26319446
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"MA at ST36, Guanyuan (CV4), and Yongquan (KI1) inhibits the recruitment and activation of hepatic macrophages via the TLR4/MyD88 and NF-κB pathways and the expression of IL-1β and TNF-α downstream, thereby improving related symptoms.23 Recent studies discovered that the NF-κB pathway is markedly inhibited by the deacetylase sirtuin-1 (Sirt1), which is a representative histone deacetylase (HDAC)."
34992414
sparser
"The gram-negative bacterial cell wall component LPS and IL-1β, which bind to Toll-Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
sparser
"Our results also propose that IL-1β may bind to TLR4, in addition to its cognate receptor IL-1R1, to exert its inflammatory effects in microglia, which is a novel finding and needs to be further explored."
26838598
sparser
"Also, IL-1β binds TLR4, thus activating B cells through the NF-kB pathway."
39590862
sparser
"TLR4 is closely associated with stress-induced inflammation and the secretion of IL-1β."
34000276
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"The four SNPs that had significant single SNP associations with either IL-1alpha (IL-1RAP rs6444435) or IL-1beta (IL-1R2 - rs4851527 and rs4851531, IL-1RAP - rs6765375) in AA were tested for interaction effects with the two SNPs in TLR4 (rs1554973 and rs7856729) that were associated with IL-1alpha and IL-1beta in European Americans in a previous study."
21704385
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"These findings extended the above mentioned studies in demonstrating that RLX could ameliorate NLRP3 inflammasome activity in myofibroblasts to inhibit the pro fibrotic interaction between TGF-beta1, TLR-4 and IL-1beta and IL-18 (XREF_FIG) on myofibroblast differentiation and myofibroblast induced interstitial collagen deposition."
32848798
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"However, a definite association between TLR-4, IL-1α, IL-1β, IL-6, and IL-10 gene polymorphisms and PTB in diverse ethnic and environmental settings has not been demonstrated (12)."
39165357
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"6 Binding of IL-1beta to IL-1R or LPS to TLR4 causes recruitment of adopter proteins such as MyD88, IRAK, and TRAF6 to the receptor."
22833096
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"The aim of this study was to investigate the association between serum pepsinogens, serum gastrin, serum vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status in patients with various gastric precancerous lesions."
23137754
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"The gram negative bacterial cell wall component LPS and IL-1beta, which bind to Toll Like Receptor 4 (TLR4) and the IL-1 Type-I receptor (IL-1RI), respectively, play a pivotal role in this process."
21029443
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"The association between precancerous gastric lesions and serum pepsinogens, serum gastrin, vascular endothelial growth factor, serum interleukin-1 Beta, serum toll like receptor-4 levels and Helicobacter pylori Cag A status."
23137754
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"All these results reveal an interaction between IL-1β and TLR4, although the exact mechanism for this needs further investigation."
36937865
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"All these results reveal an interaction between IL-1β and TLR4, although the exact mechanism for this needs further investigation.As mentioned above, IL-1β increases ROS production."
36937865
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"The anti-tumor immune signaling pathway is inhibited when receptor TLR4 is bound by the IL1B ligand in the microenvironment."
35164166