IndraLab

Statements

USP8 inhibits docetaxel anhydrous. 13 / 13
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"Overexpression of USP8 promotes PCa cell migration and diminished docetaxel activity."
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"It also shows that USP8 overexpression suppresses docetaxel’s activity, thereby increasing EGFR and PI3K-mediated NF-kB signal activation."
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"Its overexpression increased the PCa cell migration and diminished the healing action of docetaxel in both cells.Similar to the wound healing assay, overexpression of USP8 resulted in the highest number of migrated cells for both Du145 and PC3 cells in the Transwell assay, which showed statistical significance compared to all other treatment group cells ( Figure 3B )."
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"Our findings revealed that USP8 plays an oncogenic role in PCa and can suppress docetaxel activity ."
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"Knockdown of USP8 inhibits prostate cancer cell growth , proliferation , and metastasis and promotes docetaxel 's activity by suppressing the NF-kB signaling pathway Ubiquitin-specific protease 8 ( USP8 ) has been recently reported to be involved in tumorigenesis ."
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"These results imply that USP8 plays a vital role in the development and proliferation of PCa cells, indicating that targeting USP8 for PCa treatment is a good idea.The knockdown of USP8 enhanced the anti-proliferative impact of docetaxel in the MTT assay in both PCa cell lines."
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"In contrast, USP8 knockdown was found to enhance docetaxel antitumor activity."
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"However, the role of USP8 in PCa and whether USP8 has any effects on docetaxel treatment to regulate its effects targeting to enhance docetaxel activity, which may help to suppress the docetaxel resistance in CRPC, are also unclear."
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"Besides, we also showed that knocking down of USP8 in PCa cells enhanced the anticancer activity of docetaxel whereas the overexpression of USP8 suppressed the docetaxel activity."
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"Notably, the combination treatment of docetaxel and SiUSP8 was found to have the lowest cell survival 65.1 ± 2.4% and 60.4 ± 2.1% in DU145 ( Figure 1C1 ) and PC3 ( Figure 1C2 ) cells, respectively, which were significant compared to control and individual treatments of SiUSP8 and docetaxel.On the other hand, compared to the control group, the USP8 overexpression eliminated the impact of docetaxel in PCa cells."
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"Our findings revealed that USP8 plays an oncogenic role in PCa and can suppress docetaxel activity."
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"Therefore, similar to the wound healing assay, it could be stated that USP8 overexpression increased the PCa cell migration and diminished the effect of docetaxel on PCa migration."
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"Silencing of USP8 suppresses PCa cell migration and promotes docetaxel activity."
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