IndraLab

Statements

USP44 activates Chromosomal Instability. 7 / 8
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"Overexpression of USP44 leads to CIN."
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"Finally, we investigated whether high USP44 expression caused CIN."
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"A previous study reported that overexpression of USP44 in mouse embryonic fibroblasts induced CIN 13."
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"These results indicate that stable overexpression of USP44 leads to CIN in a human cell line."
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"USP44 , which belongs to USP family , can induce chromosome instability , resulting in DNA aneuploidy in GC ( Zhang et al ., 2011 ; Nishimura et al ., 2017 ) ."
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"Aberrant expression of USP44 leads CIN in cells; however, the correlation between USP44 and DNA aneuploidy in gastric cancer is largely unknown."
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"We conclude that USP44 levels are increased in T-ALL and that USP44 induced CIN may contribute to the pathogenesis of this disease."
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