IndraLab

Statements

CD4 binds CD274. 17 / 17
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"In the mouse model examined, cross-dressing was associated with enhanced expression of PD-L1 on myeloid DC and reduced presentation of allopeptide + self-MHC complexes together with increased PD-L1 on plasmacytoid DC that was associated with PD-L1-dependent CD4 + T cell anergy."
30036199
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"When this PD-L1 pathway was curbed during an in vitro-based interaction between CD4 + T cells and PD-L1 high macrophages, the expressions of CD25 and CD69 were substantially increased in CD4 + T cells which was further assisted by an improved cell proliferation rate [ xref ]."
33142805
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"Furthermore, the blocking experiment showed that blocking the PD-L1 interaction between iloprost-treated BM-DCs and naïve CD4 + T cells significantly suppressed the frequency of EGFP (Foxp3) + Tregs, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overall, the five regions identified through spatial clustering were assigned based on the predominant immune cell types, including B cells, T cells, Th cells, PD–L1–expressing cells, and PD–L1:CD4 co–expressing cells, which reflect the key immune interactions within the tissue microenvironment."
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"Regulatory T cell expansion is dependent upon the interaction between endothelial cell expression of PD-L1 and CD4 + T cell expression of PD-L1 ligand [9] ."
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"We found that PD-L1-mediated suppression of WT CD4 + T cells was associated with an increase in dead cells by 30%."
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"We describe two T-cell spatial profiles across primary PCa, a clustered immune spatial (CIS) profile characterized by dense clusters of CD4 + T cells closely interacting with PD-L1 + cells, and a free immune spatial (FIS) profile of CD8 + cells in close proximity to tumor cells."
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"Tumor cells may express inhibitory ligands, like programmed death ligand 1 (PD-L1), which binds to the inhibitory receptor, PD-1, on CD4 and CD8 T cells and inhibits their proliferation and effector f[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Expression of PD-L1 is associated with the inhibition of autoreactive CD4 + T cell responses and peripheral T cell tolerance [ xref ]."
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"However, it is unclear which PD1 + cells interact with PDL1 + CD4 + effector T cells in the TME and/or whether there is self-inhibition among T H 1 cells."
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"However, another study showed that the CD13 + CD4 + CD25 hi Treg subpopulation exhibits stronger suppressive function among CD4 + CD25 hi Treg cells by expressing a higher level of Foxp3, CTLA-4, membrane bound TGF-beta1, and B7H1."
31848300
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"In order to further understand the mechanism of the PD-1/PD-L1 pathway, the associations between PD-L1, CD3 and CD4 were investigated, but there were limitations in detecting PD-1 expression due to the availability of samples; hence, a new cohort of patients may be required for further study.In conclusion, the data of the present study demonstrated that the numbers of CD4 TILs as detected by IHC were associated with the clinical outcome of patients with HNSCC."
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"A possible mechanism by which both MDSCs and Tregs reinforce each other is the interaction between PD-L1 of MDSCs and PD-1 of CD4 + T cells [7] ."
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"MSCs treated with IFN γ also can express inhibitory costimulatory molecules such as B7 family coregulatory molecules B7-H1 [ xref ], which can interact with CD4 + lymphocytes and block cell proliferation, promoting T cell anergy."
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"Results herein show that in these diseases fewer Abeta specific CD4 + T cells can bind scarcer quantities of PD-L1 molecules on the surface of CD14 + APC."
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"Furthermore, multivariate analysis using the Cox proportional hazards model indicated that CD4 and PD-L1 were significantly associated with OS and DFS after adjusting for age (for OS, CD4: HR=0.35, 95% CI: 0.15-0.86 and P=0.006; and PD-L1: HR=2.29, 95% CI: 0.89-5.86, P=0.025; for DFS, CD4: HR=0.33, 95% CI: 0.14-0.80 and P=0.009; and PD-L1: HR=2.24, 95% CI: 0.90-5.57 and P=0.051; xref )."
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"These findings prompted us to investigate the association between CD8, CD4, PD-1, and PD-L1 positive cell densities at baseline and treatment outcome (XREF_FIG)."
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