IndraLab

Statements

CD4 binds CD274. 12 / 12
| 3 9
sparser
"Expression of PD-L1 is associated with the inhibition of autoreactive CD4 + T cell responses and peripheral T cell tolerance [ xref ]."
22285847
reach
"Results herein show that in these diseases fewer Abeta specific CD4 + T cells can bind scarcer quantities of PD-L1 molecules on the surface of CD14 + APC."
21514692
sparser
"We describe two T-cell spatial profiles across primary PCa, a clustered immune spatial (CIS) profile characterized by dense clusters of CD4 + T cells closely interacting with PD-L1 + cells, and a free immune spatial (FIS) profile of CD8 + cells in close proximity to tumor cells."
35764368
sparser
"When this PD-L1 pathway was curbed during an in vitro-based interaction between CD4 + T cells and PD-L1 high macrophages, the expressions of CD25 and CD69 were substantially increased in CD4 + T cells which was further assisted by an improved cell proliferation rate [123] ."
33142805
sparser
"However, it is unclear which PD1 + cells interact with PDL1 + CD4 + effector T cells in the TME and/or whether there is self-inhibition among T H 1 cells."
34155388
sparser
"In the mouse model examined, cross-dressing was associated with enhanced expression of PD-L1 on myeloid DC and reduced presentation of allopeptide + self-MHC complexes together with increased PD-L1 on plasmacytoid DC that was associated with PD-L1-dependent CD4 + T cell anergy."
30036199
reach
"These findings prompted us to investigate the association between CD8, CD4, PD-1, and PD-L1 positive cell densities at baseline and treatment outcome (XREF_FIG)."
25428505
reach
"However, another study showed that the CD13 + CD4 + CD25 hi Treg subpopulation exhibits stronger suppressive function among CD4 + CD25 hi Treg cells by expressing a higher level of Foxp3, CTLA-4, membrane bound TGF-beta1, and B7H1."
31848300
sparser
"MSCs treated with IFN γ also can express inhibitory costimulatory molecules such as B7 family coregulatory molecules B7-H1 [ xref ], which can interact with CD4 + lymphocytes and block cell proliferation, promoting T cell anergy."
29181035
sparser
"When this PD-L1 pathway was curbed during an in vitro-based interaction between CD4 + T cells and PD-L1 high macrophages, the expressions of CD25 and CD69 were substantially increased in CD4 + T cells which was further assisted by an improved cell proliferation rate [ xref ]."
33142805
sparser
"A possible mechanism by which both MDSCs and Tregs reinforce each other is the interaction between PD-L1 of MDSCs and PD-1 of CD4 + T cells [7] ."
27320602
sparser
"We found that PD-L1-mediated suppression of WT CD4 + T cells was associated with an increase in dead cells by 30%."
28184224