IndraLab

Statements

PRPF8 activates RNA splicing. 3 / 3
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"Further examples include human LINE-1 and other eukaryotic non-LTR retrotransposon RTs, which evolved variations of their reverse transcription and DNA integration mechanisms adapted to eukaryotic genomes and nuclear-cytoplasmic compartmentalization, and the core spliceosomal protein PRP8, which evolved from a group II intron-like RT and promotes RNA splicing by binding small nuclear RNAs derived from group II intron RNA domains (72)."
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"Other striking examples are the evolution of mobile group II introns or their close relatives into the eukaryotic RNA splicing apparatus, including the core spliceosomal protein PrP8, which evolved from a group II intron-like RT and promotes RNA splicing by interacting with snRNAs, which evolved from group II intron RNA domains, as well as closely related RTs encoded by LINE and other eukaryotic non-LTR retrotransposons, which use variations of the reverse transcription and DNA integration mechanisms adapted to eukaryotic genomes and nuclear-cytoplasmic compartmention."
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"Alterations of PRPF8 increase the proliferation of CD34+ primary bone marrow cells and of a myeloid cell line, as well as resulting in defects of the second step of the RNA splicing process [58]."
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