IndraLab

Statements

USP8 inhibits localization. 3 / 3
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"Moreover, we found that USP8 prevents Smo localization to early endosomes that are labeled with Rab5."
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"However, in the case of USP8, phosphorylation at Ser680 is also critical for its subcellular localization since mutation of Ser680 to Ala restricts its localization to the nucleus, whereas the wild type is predominantly localized into the cytosol essential for USP8 interaction with the protein 14-3-3ε [57]."
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"USP8 Prevents the Localization of Smo to the Early Endosome."
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