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"To further interrogate the interaction between FHF2 isoforms and Nav1.1, we also examined another mutation in Nav1.1, P1894L, which is associated with epilepsy and mild intellectual disability [ xref ]."

"Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels."