IndraLab

Statements

USP25 increases the amount of EZH2. 8 / 8
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"USP21 promotes cell proliferation by maintaining the EZH2 level in diffuse large B-cell lymphoma."
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"The deubiquitinase USP21 promotes cell proliferation by maintaining the EZH2 protein level in DLBCL."
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"Furthermore, we then identify USP21 modulates the protein level of EZH2, a key regulatory gene of DLBCL growth."
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"Mechanistically, USP21 promotes cell growth by maintaining EZH2 protein level."
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"Moreover, the inhibition of USP21 could decrease the expression of EZH2; while adding MG132, the expression of EZH2 was revived."
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"Accordantly, the results of western blot confirmed that knockdown of USP25 distinctly suppressed the expression of Bcl-2, c-Myc, EZH2 and PCNA, while promoted the expression of cleaved-caspase-3 and B[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we identified that USP21 directly regulated the protein level of EZH2 through its DUB activity."
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"By maintaining EZH2 protein levels, USP21 promotes cell proliferation and metastasis in bladder carcinoma and cell proliferation in diffuse large B-cell lymphoma (Chen et al., 2017b; Ma et al., 2021)."
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