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USP44 inhibits cell population proliferation. 37 / 37
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"USP44 overexpression inhibited the proliferation and migration of 786-O cells and Caki-1 cells significantly."
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"USP44 knockdown enhanced the proliferation and migration of 786-O cells and Caki-1 cells."
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"USP44 overexpression inhibits proliferation of 786-O cells and Caki-1 cells."
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"USP44 overexpression reduced the BrdU-absorption capacity of 786-O cells and Caki-1 cells significantly (Fig. 2g, h), which demonstrated that USP44 can inhibit ccRCC proliferation."
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"Taken together, these results demonstrated that USP44 inhibited proliferation of 786-O cells and Caki-1 cells."
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"These results confirmed that USP44 knockdown enhanced the proliferation and migration of Caki-1 cells."
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"Results showed that the ability of USP44 knockdown to promote the proliferation and migration of 786-O cells and Caki-1 cells was reduced significantly after treatment with a JNK inhibitor."
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"Using 786-O cells and Caki-1 cells, we showed that USP44 overexpression inhibited proliferation of these two cell lines."
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"We confirmed that USP44 deletion significantly promoted the proliferation of tumor cells through immunofluorescence of proliferating cell nuclear antigen (PCNA) in tumor samples (Fig. 1G, J)."
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"USP44 inhibits HCC proliferation and metastasis in vitro and in vivo."
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"USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
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"In contrast, USP44 overexpression reduced the proliferation and migration ability of tumor cells in HCC (Figure 4A)."
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"USP44 inhibits the proliferation and migration of HCC cells by suppressing the Hh signaling pathway in vitro."
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"USP44 functions as a tumor suppressor to inhibit cell proliferation and metastasis in OSCC both in vivo and in vitro."
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"USP44 inhibits proliferation, self-renewal, migration, and invasion of OSCC cells in vitro."
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"Our results demonstrated that USP44 overexpression reduced HCC proliferation by arresting the cell cycle at G0/G1."
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"In contrast, the knockdown of USP44 enhanced cell growth, whereas Itch overexpression mitigated the increase in cell proliferation enhanced by USP44 knockdown (Supplementary Fig. 4A–C)."
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"On the contrary, due to the tumor-suppressing role of Fructose-1,6-bisphosphatase (FBP1), the deubiquitinating role of USP44 stabilizing FBP1 suppressed tumor proliferation, metastasis and increased g[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP44 was also reported to inhibit cell proliferation in colorectal cancer [21], clear cell renal cell carcinoma [23], and non–small cell lung cancer [24]."
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"Zhang et al. showed that the expression level of USP44 was markedly decreased in colorectal cancer, and USP44 overexpression inhibited proliferation and enhanced apoptosis in colorectal cancer cells (Huang et al., 2020)."
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"A recent study demonstrated that USP44 overexpression inhibited the proliferation and migration of clear cell renal cell carcinoma cell lines; inversely, USP44 knockdown exerted opposite effects (Zhou et al., 2020)."
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"Together, these findings suggested that overexpression of USP44 inhibited cellular proliferation and migration through inhibition of the Hh pathway in vitro."
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"Knockdown of USP44 inhibited proliferation, migration and invasion, induced apoptosis, and arrested cell cycle in G2/M phase in the established glioma cell lines."
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"At the same time, CCK-8 and Transwell assays also revealed that while overexpression of USP44 (pLJM1-USP44) inhibited the proliferation, migration, and invasion of CAL-27 cells, these effects were notably reversed upon HEXIM1 knockdown (Fig. 8D and E)."
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"Depletion of USP44 inhibits proliferation, migration, and invasion in glioma cell lines."
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"Overexpression of USP44 inhibited OSCC cell proliferation and metastasis both in vitro and in vivo."
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"USP44 overexpression elevated the proliferation of CCRF-CEM cells, while USP44 knockdown suppressed the proliferation of Jurkat and MOLT-4 cells."
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"Functional assays showed that increased USP44 expression notably suppressed OSCC cell proliferation, migration, invasion and cancer stem cell-like behaviors, whereas its decreased expression had the opposite effects."
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"Downregulation of USP44 expression can inhibit proliferation, migration and invasion of established glioma cell lines and induce apoptosis (85)."
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"Collectively, these data indicated that USP44 inhibited proliferation while promoted apoptosis in CRC by inhibiting Wnt/β-catenin pathway."
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"Taken together, this study demonstrates that USP44 inhibits proliferation while enhances apoptosis in CRC cells by inactivating Wnt/β-catenin pathway via Axin1 deubiquitination."
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"Subsequent in vitro and in vivo functional studies revealed that USP44 substantially suppressed the proliferation of thyroid cancer cells by impeding the G1/S transition in cell cycle."
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"In addition, the rescue of p21 partially alleviated cell cycle advancement and cell proliferation induced by the depletion of USP44."
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"As illustrated in Fig. 5 B and D, the downregulation of USP44 attenuated the circFOXO3-induced increases in cell proliferation and migration."
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"Here, we found that USP44 expression level was markedly decreased in CRC, and USP44 overexpression inhibited proliferation while enhanced apoptosis in CRC cells, suggesting that USP44 is a cancer suppressor in CRC."
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"Collectively, these data indicated that USP44 inhibited proliferation while promoted apoptosis in CRC by inhibiting Wnt and beta-catenin pathway."
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"Taken together, this study demonstrates that USP44 inhibits proliferation while enhances apoptosis in CRC cells by inactivating Wnt and beta-catenin pathway via Axin1 deubiquitination."
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