IndraLab

Statements

USP20 binds CTSL. 7 / 7
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"Co‐immunoprecipitation (co‐IP) assays demonstrated a robust interaction between endogenous USP20 and CTSL in both FaDu and HN8 cells, rather than USP14 and USP12 (Figure  xref and Figure xref )."
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"These findings not only advance our understanding of EMT regulation but also underscore the therapeutic value of targeting the USP20‐CTSL axis in epithelial cancers."
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"Next, we examined whether Diclofenac interferes with the USP20‐CTSL axis."
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"In this study, the USP20‐CTSL axis was identified as a molecular marker and potential therapeutic target for metastatic HNSCC."
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"Mechanistically, our data suggest that USP20 interacts with CTSL and promotes its expression by preventing STUB1‐mediated ubiquitination and degradation."
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"To further assess the therapeutic potential of targeting the USP20‐CTSL axis, mice inoculated with tumour cells via tail vein injection were treated with the small‐molecule USP20 inhibitor G‐3A. As illustrated in the experimental scheme (Figure  xref ), compared with the control group, G‐3A significantly reduced the frequency and size of lung metastases, whereas CTSL overexpression partially restored the metastatic burden (Figure  xref )."
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"In this study, the USP20‐CTSL axis was identified as a molecular marker and potential therapeutic target for metastatic HNSCC, providing new insights for the development of USP20‐targeted therapies."
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