IndraLab
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"Collectively, we concluded that endogenous USP15 enhances the NRF1 mediated gene expression for proteasome recovery.Finally, we examined the biological relationship between USP15 and other Cap'n ' Col[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results uncover a new regulatory mechanism that USP15 activates Nrf1 against the beta-TrCP inhibition to maintain proteostasis."
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"Moreover, the siRNA mediated knockdown of endogenous USP15 reduced the protein turnover time of endogenous NRF1."
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"We also confirmed that other USP15 siRNAs can cause the mRNA induction of NRF1 (data not shown)."
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"Here, we report that USP15 (Ubiquitin Specific Protease 15) activates Nrf1 in the nucleus by stabilizing it through deubiquitination."
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"These results clearly suggest that USP15 activates the transcriptional activity of Nrf1."
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"Hence, these results strongly suggest that USP15 mediates the transcriptional activities of Nrf1."
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"A cycloheximide chase experiment also revealed that USP15 increases the turnover time of Nrf1."