IndraLab

Statements

Simvastatin inhibits IFNB1. 6 / 6
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"Independent of mevalonate and NF-kappaB, previously acknowledged anti-inflammatory mechanisms of pleiotropic statins, simvastatin selectively inhibited dsRNA induced IRF3 activation and production of TSLP and IFN-beta in COPD epithelium."
22881993
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"52 In conclusion, high-dose statin add-on therapy impaired the ability of interferon-beta to activate STAT1 and, in turn, to induce IRF-1, serum type 1 interferons, and MxA and viperin proteins."
22801747
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"These results demonstrate that high-dose statin add-on therapy blocks interferon-beta responses in vivo."
22801747
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"These data indicate that high-dose statin add-on therapy inhibits interferon-beta activity in most patients, whereas moderate doses have lesser inhibitory effects."
22801747
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"High-dose add-on statin therapy significantly blocked interferon-beta function, with less P-Y-STAT1 transcription factor activation, and reduced myxovirus resistance 1 protein and viperin protein production."
22801747
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"To determine whether statin add-on therapy impairs interferon-beta therapy induction of endogenous serum interferon-beta activity, we measured serum type 1 interferon activity and interferon induced proteins in 14 interferon-beta-treated RRMS patients under 4 different conditions (XREF_FIG)."
22801747