IndraLab

Statements

LRP1 binds MMP13. 18 / 18
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sparser
"MMP-13 directly binds to LRP1 via its Hpx domain."
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"2.4 Effect of heparin on the binding of MMP-13 to LRP1."
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sparser
"We thus examined the effect of heparin on the binding of MMP-13 to LRP1."
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"Furthermore, competition studies on the MMP-13 binding to LRP1 showed that the addition of neither MMP-1 nor MMP-13-13-1 inhibits the MMP-13 binding to LRP1, whereas Hpx MMP-13 and MMP-1-1-13 similarly inhibited the binding in a dose dependent manner (XREF_FIG D), supporting our conclusion described above."
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sparser
"LRP1 was associated with the function of MMP-13 in the physiological turnover of the ECM [ xref ]."
29126436
sparser
"Both MMP-13 and Hpx MMP-13 bound to immobilized LRP1 with K D , app values of 3.8 nM and 2.7 nM, respectively ( xref C and xref ), suggesting that Hpx MMP-13 is essential for the interaction with LRP1."
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"2.5 Binding of MMP-13 to LRP1 ligand binding clusters."
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"We thus examined the effect of heparin on the binding of MMP-13 to LRP1."
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"Interestingly, MMP-13 bound LRP-1 via its haemopexin domain at a site distinct to ADAMTS-5, ADAMTS-4 and TIMP3, which permits co-endocytosis with these proteins 101."
30828429
reach
"To identify the region (s) of LRP1 that binds to MMP-13, each recombinant cluster was coated on multi-well plates and subsequent binding of MMP-13 was quantified."
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sparser
"Effect of heparin on the binding of MMP-13 to LRP1."
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reach
"We also show here that MMP-13 directly binds to LRP1 via its hemopexin (Hpx) domain (Hpx MMP-13) and its binding clusters in LRP1 have been determined."
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sparser
"For example, low-density lipoprotein receptor-related protein 1 (LRP1) binds both pro- and activated MMP-13, and is a key modulator of the extracellular levels of MMP-13."
29126436
sparser
"Furthermore, competition studies on the MMP-13 binding to LRP1 showed that the addition of neither MMP-1 nor MMP-13-13-1 inhibits the MMP-13 binding to LRP1, whereas Hpx MMP-13 and MMP-1-1-13 similarly inhibited the binding in a dose-dependent manner ( xref D), supporting our conclusion described above."
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reach
"Intriguingly, proMMP-13 and active MMP-13 bound to LRP-1 with similar dissociation constants."
30828429
sparser
"To identify the region(s) of LRP1 that binds to MMP-13, each recombinant cluster was coated on multi-well plates and subsequent binding of MMP-13 was quantified."
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hprd
No evidence text available
10514495
reach
"2.3 MMP-13 directly binds to LRP1 via its Hpx domain."
27084377