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CACNA1G binds AS1. 109 / 109
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"Compared with the negative control, the level of miR-205 was conspicuously reduced by the overexpression of CACNA1G-AS1 and apparently promoted when keloid fibroblasts were co-transfected with miR-205 ( xref A)."
32495824
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"CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis in human keloid fibroblasts."
32495824
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"An alternative lncRNA, CACNA1G-AS1, was proven to be upregulated in 30 OC specimens and 3 OC cell lines relative to control."
34238292
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"Besides, transwell assay demonstrated that the number of invaded keloid fibroblasts was significantly increased in CACNA1G-AS1 transfected keloid fibroblasts, which was decreased by CACNA1G-AS1 silencing ( xref C)."
32495824
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"Through Western blot, RNA immunoprecipitation (RIP), and chromatin immunoprecipitation (ChIP) assay, the interaction between CACNA1G-AS1 and EZH2 was assessed."
31957825
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"Another recent study has reported that lncRNA CACNA1G-AS1 can act as competing endogenous RNAs (ceRNAs) to regulate miR-205 expression, and it promotes proliferation and invasion in human keloid fibroblasts ( xref )."
33708773
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"The result revealed that CACNA1G-AS1 significantly reduced caspase-3 activity and silenced CACNA1G-AS1 promoted caspase-3 activity ( xref E)."
32495824
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"Studies have shown that HNRNPA2B1 was up-regulated by CACNA1G-AS1, thus participating in the progression of NSCLC [ xref ]."
33428597
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"Dual luciferase reporter assay was carried out to examine the relationship between CACNA1G-AS1 and miR-205 and RNA immunoprecipitation (RIP) assay was conducted to further confirm the relation."
32495824
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"Moreover, the apoptosis of keloid fibroblasts was dramatically inhibited in keloid fibroblasts transfected with CACNA1G-AS1 compared with control groups and was then enhanced by the introduction with miR-205 ( xref G)."
32495824
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"Moreover, miR-205 level was down-regulated by CACNA1G-AS1."
32495824
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"In a previous study, the expression of lncRNA CACNA1G-AS1 (CAS1) was confirmed abnormally high in keloid tissue, suggesting that CAS1 was involved in keloid formation [ xref ]."
33243301
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"These data revealed that CACNA1G-AS1 participated in the regulation of proliferation, invasion, and apoptosis of keloid fibroblasts in vitro ."
32495824
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"As a result, 11 lncRNAs, including C4A-AS1 , LINC02408 , AC087521.1 , LINC00488 , AC010275.1 , CHRM3-AS2 , LINC00337 , Z98257.1 , AC104667.2 , SOCS2-AS1 and CACNA1G-AS1 , were identified for modeling ( xref , xref )."
33223503
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"Of note, SOCS2-AS1 and CACNA1G-AS1 can act as a ceRNA to participate in tumorigenesis and development [ xref , xref ]."
33223503
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"In the present study, we explored the relationship between CACNA1G-AS1 and miR-205 and further studied their effects on proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
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"A recent study performed by Wei revealed higher expression of CACNA1G-AS1 in colorectal cancer (CRC) tissues compared to adjacent normal tissues and found that CACNA1G-AS1 was able to enhance proliferative and invasive abilities of CRC cells by downregulating p53 via forming a carcinogenic complex with EZH2 ( xref )."
33708773
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"However, the expression and function of lncRNA CACNA1G-AS1 remain unclear in human keloid fibroblasts up to date."
32495824
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"CCK-8 assay determined that the proliferation of keloid fibroblasts was promoted by the overexpression of CACNA1G-AS1, when co-transfection with miR-205, the proliferation was significantly reduced in keloid fibroblasts ( xref C)."
32495824
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"Two additional ncRNAs were also shown to affect p53 levels: the lncRNA CACNA1G-AS1, which decreases p53 levels, is more highly expressed in CRC tissues than in adjacent normal tissue, whereas the circular RNA, circZNF609, which enhances p53 levels, shows decreased expression in CRC compared with adjacent normal tissue [ xref , xref ]."
33924934
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"QRT-PCR assay showed that CACNA1G-AS1 expression was greatly increased by CACNA1G-AS1 and was sharply inhibited by the interference of CACNA1G-AS1 ( xref A)."
32495824
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"The previous study demonstrated that the CACNA1G-AS1 expression was greatly increased in keloid relative to normal skin [ xref ]."
32495824
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"The putative binding sites between CACNA1G-AS1 and miR-205 and the mutant sequences of CACNA1G-AS1 were shown in xref A. Subsequently, to determine the interaction between them, luciferase reporter vectors were co-transfected into keloid fibroblasts with miR-205 or miR-NC."
32495824
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"Furthermore, the correlation analysis disclosed that there was an opposite trend between CACNA1G-AS1 and miR-205 expression ( xref C)."
32495824
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"Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker."
35715447
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"The lncRNA CACNA1G-AS1 expression is upregulated in keloid fibroblasts, promotes cell proliferation and invasion, and inhibits cell apoptosis [ xref ]."
34974806
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"Long non-coding RNA (lncRNA) CACNA1G-AS1 promotes the expression of hnRNPA2B1 in non-small cell lung cancer (NSCLC) cell lines, inducing malignant cell invasion, migration, and epithelial-mesenchymal transformation (EMT) ( xref )."
33505405
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"Moreover, RIP assay indicated that the introduction of miR-205 resulted in the significant enrichment of CACNA1G-AS1 in RIP-AGO2 complex compared with RIP-IgG control ( xref C)."
32495824
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"Furthermore, a lncRNA-based risk score was developed by integrating the expression data for these 11 lncRNAs with corresponding coefficients weighted by the LASSO model as follows: Risk score = (0.147 × LINC02408 expression value) + (-0.066 × LINC00488 expression value) + (-0.161 × LINC00337 expression value) + (0.104 × Z98257.1 expression value) + (-0.129 × CHRM3-AS2 expression value) + (-0.14 × C4A-AS1 expression value) + (-0.156 × AC104667.2 expression value) + (0.088 × AC087521.1 expression value) + (-0.159 × SOCS2-AS1 expression value) + (0.096 × AC010275.1 expression value) + (0.111 × CACNA1G-AS1 expression value)."
33223503
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"Of them, three lncRNAs ( LINC00189 , CACNA1G-AS1 , and AC105384.1 ) seem to be risk factors, and the remaining two lncRNAs ( AL133467.1 and CHRM3-AS2 ) are protective factors."
33708773
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"CACNA1G-AS1 was identified as a carcinogenic lncRNA which contributed to accelerate the development of OC and lead to poor prognosis [ xref ]."
36187230
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"It has been proposed that plenty of lncRNAs were closely related to the progression of keloid fibrosis [ xref ], such as HNF1A-AS1 [ xref ], COL1A2-AS1 [ xref ], CACNA1G-AS1, HOXA11-AS, LINC00312, and RP11-91I11.1 [ xref ]."
32495824
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"Computational epigenetic landscape analysis reveals association of CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 lncRNAs in prostate cancer progression through aberrant methylation."
35715447
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"Additionally, the level of CACNA1G-AS1 in keloid fibroblasts was significantly increased versus normal fibroblasts ( xref B)."
32495824
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"CACNA1G-AS1 was predicted to interact with miR-205 and miR-205 expression was down-regulated by CACNA1G-AS1."
32495824
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"Results: CACNA1G-AS1 level was up-regulated in keloid tissues and keloid fibroblasts."
32495824
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"CACNA1G-AS1 regulated proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
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"Based on the four LI-m6As (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6-AS1), the risk model we identified can independently predict the OS and therapeutic value of OC."
34238292
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"Meanwhile, the proliferation of keloid fibroblasts was greatly impeded by the interference of CACNA1G-AS1 compared with the negative control, which was significantly promoted following the transfection with anti-miR-205 ( xref D)."
32495824
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"Finally, we performed multivariate Cox regression analysis for five optimal lncRNA biomarkers and constructed a lncRNA-based risk score model based on the linear combination of the expression of five optimal lncRNA biomarkers, weighted by their coefficients from the multivariate regression analysis as follows: EpiLncRNASig = (0.197) ∗ expression ( LINC00189 ) + (0.167) ∗ expression ( CACNA1G-AS1 ) + (−0.432) ∗ expression ( AL133467.1 ) + (−0.374) ∗ expression ( CHRM3-AS2 ) + (0.395) ∗ expression ( AC105384.1 )."
33708773
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"CACNA1G-AS1 was highly expressed in keloid tissues and keloid fibroblasts."
32495824
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"Knockdown of the long non-coding RNA CACNA1G-AS1 enhances cytotoxicity and apoptosis of human diffuse large B cell lymphoma by regulating miR-3160-5p."
36160896
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"The present study was aim to illuminate the mechanism of calcium voltage-gated channel subunit alpha1 G antisense RNA 1 (CACNA1G-AS1) in human keloid fibroblasts."
32495824
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"Similarly, miR-205 level was increased by the knockdown of CACNA1G-AS1, however, was then decreased by transfection with anti-miR-205 ( xref B)."
32495824
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"However, there is no relevant study on the interaction between CACNA1G-AS1 and miR-205 in keloid fibroblasts."
32495824
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"By bioinformatic analysis, Liang et al. constructed a coding–non-coding gene co-expression diagram, and found that 1731 lncRNAs constantly up-regulated and lncRNA CACNA1G-AS1 may be crucial for keloid formation [ xref ]."
33243301
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"CACNA1G-AS1 was highly expressed in keloid tissues and keloid fibroblasts, and CACNA1G-AS1 regulated proliferation, invasion, and apoptosis in keloid fibroblasts."
32495824
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"All above data implied that miR-205 was targeted by CACNA1G-AS1."
32495824
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"CACNA1G-AS1 has been proved to associate with progression in multiple diseases, such as hepatocellular carcinoma, non-small cell lung cancer (NSCLC) and keloid."
32495824
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"However, the specific role and mechanism of CACNA1G-AS1 have not been fully elucidated in human diffuse large B cell lymphoma (DLBCL)."
36160896
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"In the present study, CACNA1G-AS1 expression was verified in DLBCL tissues and cells by reverse transcription-quantitative PCR, and the relationship between CACNA1G-AS1 and microRNA (miR)-3160-5p was confirmed using luciferase reporter assays."
36160896
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"The data suggested that CACNA1G-AS1 might be a novel treatment target for keloids."
32495824
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"By analyzing CACNA1G-AS1 expression levels in 122 pairs of non-small cell lung cancer (NSCLC) and normal tissue samples as well as in NSCLC cell lines, xref identified CACNA1G-AS1 as an oncogene to promote cell migration, invasion, and epithelial-mesenchymal transition via regulating HNRNPA2B1 ."
33708773
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"Furthermore, knockdown of CACNA1G-AS1 was proven to restrain the multiplication capacity of OC cells."
34238292
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"CACNA1G-AS1 modulated proliferation, invasion, and apoptosis of keloid fibroblasts by binding miR-205."
32495824
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"It was revealed that CACNA1G-AS1 was highly expressed in DLBCL tissues and cells and that expression of CACNA1G-AS1 was associated with the clinical stage of DLBCL."
36160896
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"CACNA1G‐AS1 promoted the progression of HCC via competitively binding miR‐2392 and alleviating its inhibition on C1orf61. xref MCM3AP‐AS1 promoted the expression of FOXA1 through targeting miR‐194‐5p and thus exerted an oncogenic role in HCC. xref DSCR8 facilitated the activation of the Wnt/β‐catenin signaling pathway in HCC via the DSCR8/miR‐485‐5p/FZD7 axis. xref A few studies identified HCC‐related potential prognostic biomarkers via the construction of the ceRNA network. xref , xref , xref However, they were based on online tools that failed to take complex interactions among genes or disease‐specific data features into account."
33232580
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"Furthermore, CACNA1G-AS1 and miR-205 played the antagonistic role in miR-205 expression, proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
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"These findings provided new evidence for the better understanding of CACNA1G-AS1 and a novel potential diagnostic target of keloid."
32495824
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"Li et al. reported that CACNA1G-AS1 promoted the cell migration of keloid fibrosis [ xref ]."
32495824
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"Then the results of CCK-8 assay suggested that overexpression of CACNA1G-AS1 notably promoted the proliferation of keloid fibroblasts and the silence of CACNA1G-AS1 had the opposite effect on proliferation with CACNA1G-AS1 overexpression ( xref B)."
32495824
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"In an experimental study, HNRNPA2B1, regulated by CACNA1G-AS1, increased the epithelial–mesenchymal transition of NSCLC cells ( xref )."
36246622
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"CACNA1G-AS1 was preliminarily proved to be a malignant lncRNA."
34238292
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"All of the above results revealed that lncRNA CACNA1G-AS1 enhanced proliferation and invasion and inhibited apoptosis by sponging miR-205 in human keloid fibroblasts."
32495824
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"On the other hand, lncRNAs such as CACNA1G-AS1 (CAS1) and lncRNA activated by TGF-β (lncRNA-ATB) affect keloid formation."
35696989
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"CACNA1G-AS1 and miR-205 levels were detected using quantitative real-time polymerase chain reaction (qRT-PCR)."
32495824
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"In addition, CACNA1G-AS1 could downregulate miR-3160-5p by targeting binding in DLBCL cells."
36160896
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"Next, the potential targets of CACNA1G-AS1 were predicted using LncBase Predicted v."
32495824
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"A prognostic signature containing four LI-m6As (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6-AS1) was constructed according to the LASSO Cox regression analysis of the 10 LI-m6As."
34238292
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"To explore the interaction between CACNA1G-AS1 and miR-205 in keloid fibroblasts, fibroblast cells were transfected with pcDNA, CACNA1G-AS1, si-NC, or si-CACNA1G-AS1."
32495824
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"As shown in xref , three lncRNAs ( LINC00189 , CACNA1G-AS1 , and AC105384.1 ) revealed significantly higher expression in the high-risk group compared to those in the low-risk group, and two lncRNAs ( AL133467.1 and CHRM3-AS2 ) are significantly upregulated in the low-risk group and down-regulated in the high-risk group ( xref )."
33708773
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"CACNA1G-AS1 directly interacted with miR-205."
32495824
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"These results indicated that CACNA1G-AS1 might play a role in the development of human keloid fibroblasts."
32495824
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"Recent study demonstrated that calcium voltage-gated channel subunit alpha1 G antisense RNA 1 (CACNA1G-AS1) was up-regulated in keloid and had a positive effect on cell migration in keloid fibrosis [ xref ]."
32495824
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"Microarray profiling of long noncoding RNAs (lncRNAs) has also been performed in lesional keloid tissue, identifying altered expression of CACNA1G-AS1 and HNF1A-AS1, which interact not only with pro-fibrotic TGF-β pathways, but also with cellular adhesion and tight junction signaling [ xref , xref ]."
33202590
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"Dysregulated long non-coding RNAs (lncRNAs) such as LINC00189, CACNA1G-AS1, and CHRM3-AS2 have been implicated in ovarian cancer initiation and the progress, highlighting their promising functions as markers of precision medicine ( xref )."
34671615
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"CACNA1G-AS1 overexpression and knockdown exerted the opposite roles in proliferation, invasion and apoptosis of keloid fibroblasts, suggesting that CACNA1G-AS1 was closely related to progression of keloid fibroblasts."
32495824
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"LncRNA CACNA1G-AS1 was identified to be upregulated in 30 OC specimens and 3 OC cell lines, while its knockdown restrained the multiplication capacity of OC cells ( xref )."
35003214
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"This study was aim to illuminate the mechanism of Calcium Voltage-Gated Channel Subunit Alpha1 G antisense RNA 1 (CACNA1G-AS1) in human keloid fibroblasts."
32495824
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"The overexpression of CACNA1G-AS1 in hepatocellular carcinoma patients was linked to a low survival rate [ xref ]."
33223503
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"Also, transwell assay indicated that the overexpression of CACNA1G-AS1 promoted the invasion of keloid fibroblasts which was then decreased by co-transfection with miR-205 ( xref E)."
32495824
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"Expression level of miR-205 was drastically decreased in keloid tissues and keloid fibroblasts and was negatively regulated by CACNA1G-AS1."
32495824
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"In comparison, the remaining six lncRNAs ( PCOLCE-AS1 , MEF2C-AS1 , LINC01558 , HOXB-AS2 , CACNA1G-AS1 and AC026904.1 ) and ten mRNAs ( ZCCHC24 , NBL1 , SLC22A3 , GFPT2 , LRRC17 , TCF15 , PTGIS , FSTL3 , PRDM6 and ARHGAP6 ) were positively associated with OS ( P < 0.05)."
33223503
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"For example, the lncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression via the miR-2392/C1orf61 pathway[ xref ]."
32351291
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"Dual luciferase reporter and RIP assays also confirmed the directly interaction between CACNA1G-AS1 and miR-205."
32495824
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"Methods: CACNA1G-AS1 and miR-205 levels were detected using quantitative real-time polymerase chain reaction (qRT-PCR)."
32495824
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"Conclusion: CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis in human keloid fibroblasts."
32495824
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"The results showed that caspase-3 activity was promoted by silenced CACNA1G-AS1 and was then inhibited when co-transfection with anti-miR-205, which further confirmed the interaction between CACNA1G-AS1 and miR-205 in apoptosis of keloid fibroblasts ( xref I,J)."
32495824
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"QRT-PCR results determined that the expression of miR-205 was significantly reduced in keloid fibroblasts transfected with CACNA1G-AS1 and was greatly promoted by the knockdown of CACNA1G-AS1 ( xref D)."
32495824
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"Furthermore, we discovered that CACNA1G-AS1 and miR-205 had the opposite function in proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
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"CACNA1G-AS1 overexpression promoted proliferation and invasion and suppressed apoptosis of keloid fibroblasts."
32495824
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"Compared with the normal skin tissues, CACNA1G-AS1 expression was noticeably elevated in keloid tissues ( n =20) ( xref A)."
32495824
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"For example, research conducted about lncRNA-ATB suggested a signaling axis composition of ZNF217/TGF-β2/miR-200c/lncRNA-ATB, and there has also been an association reported between keloids and CACNA1G-AS1, HOXA11-AS, LINC00312 and other lncRNAs ( xref , xref )."
32309369
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"In the present study, we illuminated the role of CACNA1G-AS1 and the molecular mechanism between CACNA1G-AS1 and miR-205 in human keloid fibroblasts."
32495824
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"These findings implied that CACNA1G-AS1 regulated proliferation, invasion and apoptosis of keloid fibroblasts through suppressing miR-205 expression."
32495824
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"Meantime, the invasion of keloid fibroblasts was largely blocked by CACNA1G-AS1 silencing, while the invasion of keloid fibroblasts was significant increased when transfected with si-CAC + anti-miR-205 ( xref F)."
32495824
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"In total, miR-205 was lowly expressed in keloids tissues and keloid fibroblasts and miR-205 expression was modulated by CACNA1G-AS1."
32495824
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"3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients."
35715447
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"Interestingly, miR-205 expression was oppositely correlated with CACNA1G-AS1 expression."
32495824
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"Long non-coding RNA CACNA1G-AS1 promotes proliferation and invasion and inhibits apoptosis by regulating expression of miR-205 in human keloid fibroblasts."
32495824
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"First, qRT-PCR was conducted to detect the expression level of CACNA1G-AS1 in normal skin tissues, keloid tissues, normal fibroblasts, and keloid fibroblasts."
32495824
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"Moreover, the apoptosis of keloid fibroblasts was markedly inhibited by CACNA1G-AS1 overexpression and was promoted by the transfection with si-CACNA1G-AS1 ( xref D)."
32495824
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"Consistent with above studies, we discovered that CACNA1G-AS1 level was significantly increased in keloid tissues and keloid fibroblasts."
32495824
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"Finally, real-time qPCR analysis and cell counting kit-8 assays were performed on an alternative lncRNA, CACNA1G-AS1."
34238292
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"Moreover, miR-205 was targeted by CACNA1G-AS1 and miR-205 was markedly decreased in keloid tissues and keloid fibroblasts."
32495824
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"Also, miR-205 expression was negatively regulated by CACNA1G-AS1 and miR-205 silencing enhanced proliferation and invasion and inhibited apoptosis."
32495824
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"To examine the role of CACNA1G-AS1 in keloid fibroblasts proliferation, invasion, and apoptosis, the keloid fibroblasts were transfected with pcDNA, CACNA1G-AS1, si-NC, or si-CACNA1G-AS1."
32495824
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"Moreover, lncRNA CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis of human keloid fibroblasts."
32495824
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"CACNA1G-AS1 level was up-regulated in keloid tissues and keloid fibroblasts."
32495824