IndraLab

Statements

Delta-actitoxin-Avd1a binds CACNA1G. 203 / 203
| 203
sparser
"According to these results, we concluded that CACNA1G-AS1 could upregulate FTH1 via IGF2BP1-mediated m6A methylation in ovarian cancer cells."
37304234
sparser
"CACNA1G-AS1 inhibits ferritinophagy and ferroptosis through the IGF2BP1-FTH1 axis in ovarian cancer cells."
37304234
sparser
"CACNA1G-AS1 overexpression promoted proliferation and invasion and suppressed apoptosis of keloid fibroblasts."
32495824
sparser
"SKOV3 cells were transfected with plasmids containing RNA mimics and inhibitors (CACNA1G-AS1, IGF2BP1 and FTH1) to construct ovarian cancer cell models with different pathway expression states."
37304234
sparser
"For example, CACNA1G-AS1 was shown to decrease proliferation, EMT transition, and migration in hepatocellular carcinoma ( xref ) and non-small cell lung cancer ( xref ) and to downregulate p53 levels in colorectal cancer ( xref )."
37084275
sparser
"Additionally, the level of CACNA1G-AS1 in keloid fibroblasts was significantly increased versus normal fibroblasts ( xref B)."
32495824
sparser
"Moreover, lncRNA CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis of human keloid fibroblasts."
32495824
sparser
"Among them, AC008669.1, ACAP2-IT1, AL138820.1 and CACNA1G-AS1 was associated with poor prognosis of OC, while AC010336.1, AC097376.3 and AC130710.1 was protective factor for the prognosis of OC."
35676619
sparser
"These results indicated that CACNA1G-AS1 might play a role in the development of human keloid fibroblasts."
32495824
sparser
"CACNA1G-AS1 regulated proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
sparser
"To examine the role of CACNA1G-AS1 in keloid fibroblasts proliferation, invasion, and apoptosis, the keloid fibroblasts were transfected with pcDNA, CACNA1G-AS1, si-NC, or si-CACNA1G-AS1."
32495824
sparser
"Li et al. reported that CACNA1G-AS1 promoted the cell migration of keloid fibrosis [ xref ]."
32495824
sparser
"CACNA1G-AS1 was demonstrated to have significantly higher expression in several cancer, such as ovarian cancer and non-small cell lung cancer xref , xref ."
35715447
sparser
"Another factor is CACNA1G-AS1 , a long RNA molecule that does not code for proteins but interacts with IGF2BP1 and increases the expression of FTH1, an enzyme that regulates iron levels."
39022677
sparser
"Dual luciferase reporter and RIP assays also confirmed the directly interaction between CACNA1G-AS1 and miR-205."
32495824
sparser
"Furthermore, we discovered that CACNA1G-AS1 and miR-205 had the opposite function in proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
sparser
"Unlike CACNA1G-AS1 and NNT‑AS1, the up-regulation of F11-AS1 has been found to be associated with the suppression of liver hepatocellular carcinoma xref , xref ."
35715447
sparser
"In an experimental study, HNRNPA2B1, regulated by CACNA1G-AS1, increased the epithelial–mesenchymal transition of NSCLC cells ( xref )."
36246622
sparser
"The candidate epigenetically deregulated lncRNAs CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 might function as key regulatory factors in the development and progression of PC and could be potential therapeutic and prognostic biomarkers for PC, which were associated with the poor prognosis of the patients with PC."
35715447
sparser
"Higher expression of the hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 significantly lower the overall survival rates of the PC patients."
35715447
sparser
"Moreover, RIP assay indicated that the introduction of miR-205 resulted in the significant enrichment of CACNA1G-AS1 in RIP-AGO2 complex compared with RIP-IgG control ( xref C)."
32495824
sparser
"All above data implied that miR-205 was targeted by CACNA1G-AS1."
32495824
sparser
"The lncRNA CACNA1G-AS1 expression is upregulated in keloid fibroblasts, promotes cell proliferation and invasion, and inhibits cell apoptosis [ xref ]."
34974806
sparser
"Expression level of miR-205 was drastically decreased in keloid tissues and keloid fibroblasts and was negatively regulated by CACNA1G-AS1."
32495824
sparser
"3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs were identified as high-risk factors for poor prognosis of PC patients."
35715447
sparser
"Furthermore, the correlation analysis disclosed that there was an opposite trend between CACNA1G-AS1 and miR-205 expression ( xref C)."
32495824
sparser
"Overexpression of hypo-methylated CACNA1G-AS1, F11-AS1, and NNT-AS1 and down-regulation of hyper-methylated MSC-AS1 significantly lower the survival of PC patients and could be a potential prognostic and therapeutic biomarker."
35715447
sparser
"To explore the interaction between CACNA1G-AS1 and miR-205 in keloid fibroblasts, fibroblast cells were transfected with pcDNA, CACNA1G-AS1, si-NC, or si-CACNA1G-AS1."
32495824
sparser
"QRT-PCR results determined that the expression of miR-205 was significantly reduced in keloid fibroblasts transfected with CACNA1G-AS1 and was greatly promoted by the knockdown of CACNA1G-AS1 ( xref D)."
32495824
sparser
"In total, miR-205 was lowly expressed in keloids tissues and keloid fibroblasts and miR-205 expression was modulated by CACNA1G-AS1."
32495824
sparser
"Out of 24 pairs, a significant negative correlation [correlation coefficient (R) > − 0.3 and p-value < 0.05] was observed between the 8 DElncRNA (BMS1P4, CACNA1G-AS1, MIR9-3HG, SDK1-AS1, PPM1K-DT, F11-AS1, NNT-AS1, and MSC-AS1) and their respective 8 DMCs (cg19500311, cg23614229, cg00576773, cg23194354, cg05850997, cg23957912, cg12626968, and cg11052780) (Figs.  xref and xref )."
35715447
sparser
"Pre-ranked GSEA analysis showed that the high expression of CACNA1G-AS1 might be associated with the up-regulation of the Wilms’ tumor 1-associating protein (WTAP) targeted genes."
35715447
sparser
"CACNA1G-AS1 modulated proliferation, invasion, and apoptosis of keloid fibroblasts by binding miR-205."
32495824
sparser
"Conversely, the up-regulation of CACNA1G-AS1, MIR9-3HG, F11-AS1, and NNT-AS1 is significantly associated with the hypo-methylation of their respective CpG sites cg23614229, cg00576773, cg23957912, and cg12626968 which were found within the promoter region of these DElncRNAs."
35715447
sparser
"Compared with the negative control, the level of miR-205 was conspicuously reduced by the overexpression of CACNA1G-AS1 and apparently promoted when keloid fibroblasts were co-transfected with miR-205 ( xref A)."
32495824
sparser
"On the other hand, lncRNAs such as CACNA1G-AS1 (CAS1) and lncRNA activated by TGF-β (lncRNA-ATB) affect keloid formation."
35696989
sparser
"Univariate Cox regression analysis identified 3 (cg23614229, cg23957912, and cg11052780) DMCs and 4 (CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1) DElncRNAs as high-risk factors (95% CI HR ⊉ 1 and p-value < 0.05) for the prognosis of patients with Prostate cancer (Fig.  xref )."
35715447
sparser
"CACNA1G-AS1 has been proved to associate with progression in multiple diseases, such as hepatocellular carcinoma, non-small cell lung cancer (NSCLC) and keloid."
32495824
sparser
"Hypo-methylation of two DMCs cg23614229 (within the promoter region of CACNA1G-AS1), and cg23957912 (within the promoter region of F11-AS1) were found to significantly responsible for the poor prognosis of the patients with Prostate cancer (95% CI HR < 1 and p-value < 0.05)."
35715447
sparser
"Similarly, miR-205 level was increased by the knockdown of CACNA1G-AS1, however, was then decreased by transfection with anti-miR-205 ( xref B)."
32495824
sparser
"Higher expression (95% CI HR > 1) of CACNA1G-AS1, F11-AS1, and NNT-AS1 were found to significantly lower the overall survival rates of the patients with Prostate cancer than those of patients with lower expression of these DElncRNAs (Figs.  xref and xref )."
35715447
sparser
"CCK-8 assay determined that the proliferation of keloid fibroblasts was promoted by the overexpression of CACNA1G-AS1, when co-transfection with miR-205, the proliferation was significantly reduced in keloid fibroblasts ( xref C)."
32495824
sparser
"Studies have shown that HNRNPA2B1 was up-regulated by CACNA1G-AS1, thus participating in the progression of NSCLC [ xref ]."
33428597
sparser
"The previous study demonstrated that the CACNA1G-AS1 expression was greatly increased in keloid relative to normal skin [ xref ]."
32495824
sparser
"Yu et al. demonstrated that CACNA1G-AS1 promoted NSCLC cell migratory and invasive abilities through regulating HNRNPA2B1 [ xref ]."
35441574
sparser
"Functional enrichment analysis was accomplished to identify the potential molecular functions and the underlying biological processes in which CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 are involved."
35715447
sparser
"In terms of this, lncRNA-mRNA interaction network was determined to figure out the protein-coding genes whose expression can be modulated by the CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 lncRNAs."
35715447
sparser
"This analysis identified a total of 30 protein-coding genes, 18 of which can be modulated by the NNT-AS1, whereas MSC-AS1, and CACNA1G-AS1 can modulate 9, and 3 protein-coding genes, respectively (Fig.  xref )."
35715447
sparser
"Meanwhile, the proliferation of keloid fibroblasts was greatly impeded by the interference of CACNA1G-AS1 compared with the negative control, which was significantly promoted following the transfection with anti-miR-205 ( xref D)."
32495824
sparser
"Also, transwell assay indicated that the overexpression of CACNA1G-AS1 promoted the invasion of keloid fibroblasts which was then decreased by co-transfection with miR-205 ( xref E)."
32495824
sparser
"594 Inhibition of miR-2392 by the long-non-coding RNA CACNA1G‐AS1 was found to promote 595 hepatocellular carcinoma through disrupting the degradation of C1orf61, a tumor activator 596 associated with metastasis and tumor progression (Hu et al., 2013; Yang et al., 2019)."
33948587
sparser
"CACNA1G-AS1 targeted RPL37A, HDAC11 genes were identified to associate with RNA binding, and histone deacetylase activity (Fig.  xref )."
35715447
sparser
"Meantime, the invasion of keloid fibroblasts was largely blocked by CACNA1G-AS1 silencing, while the invasion of keloid fibroblasts was significant increased when transfected with si-CAC + anti-miR-205 ( xref F)."
32495824
sparser
"CACNA1G-AS1 negatively correlated with the HORIUCHI_WTAP_TARGETS_UP set, means down-regulation of the CACNA1G-AS1 negatively correlates with the up-regulation of the Wilms' tumor 1-associating protein (WTAP) targeted genes (Fig.  xref b)."
35715447
sparser
"Moreover, the apoptosis of keloid fibroblasts was dramatically inhibited in keloid fibroblasts transfected with CACNA1G-AS1 compared with control groups and was then enhanced by the introduction with miR-205 ( xref G)."
32495824
sparser
"Dysregulated long non-coding RNAs (lncRNAs) such as LINC00189, CACNA1G-AS1, and CHRM3-AS2 have been implicated in ovarian cancer initiation and the progress, highlighting their promising functions as markers of precision medicine ( xref )."
34671615
sparser
"The results showed that caspase-3 activity was promoted by silenced CACNA1G-AS1 and was then inhibited when co-transfection with anti-miR-205, which further confirmed the interaction between CACNA1G-AS1 and miR-205 in apoptosis of keloid fibroblasts ( xref I,J)."
32495824
sparser
"Through Western blot, RNA immunoprecipitation (RIP), and chromatin immunoprecipitation (ChIP) assay, the interaction between CACNA1G-AS1 and EZH2 was assessed."
31957825
sparser
"Recently, a study confirmed that lncRNA CACNA1G-AS1 was obviously upregulated in OC samples."
38725621
sparser
"Further analysis uncovered that CACNA1G-AS1 could inhibit ferroptosis through increasing the expression of FTH1 via IGF2BP1 axis, thus promoting proliferation and migration in OC cells."
38725621
sparser
"In addition, in vivo studies revealed that knockdown of CACNA1G-AS1 could increase the sensitivities of OC cells to ferroptosis ( xref )."
38725621
sparser
"A significant inverse correlation was found between the promoter methylation (cg19500311, cg23614229, cg00576773, cg23194354, cg05850997, cg23957912, cg12626968, and cg11052780) of 8 corresponding aberrantly expressed DElncRNAs (BMS1P4, CACNA1G-AS1, MIR9-3HG, SDK1-AS1, PPM1K-DT, F11-AS1, NNT-AS1, and MSC-AS1)."
35715447
sparser
"Among lncRNAs with diagnostic and prognostic values, HOTAIR, xref , xref , xref HOTTIP, xref PEG10, xref , xref LUNAR1, xref HULC, xref TUG1, xref TRIM52‐AS1, xref TRERNA1, xref CACNA1G‐AS1 xref and SNHG16 xref were upregulated, but NONHSAT120161, xref GAS5, xref OR2A1‐ AS1 xref , xref and PANDA xref were downregulated."
37246627
sparser
"These findings implied that CACNA1G-AS1 regulated proliferation, invasion and apoptosis of keloid fibroblasts through suppressing miR-205 expression."
32495824
sparser
"The lncRNA CACNA1G-AS1 has been identified as a key player in inhibiting ferroptosis, which supports the survival and growth of tumor cells."
39941838
sparser
"CACNA1G-AS1 achieves this by upregulating ferritin heavy chain 1 (FTH1), which in turn leads to a reduction in mitochondrial autophagy."
39941838
sparser
"Conversely, significant up-regulation of the CACNA1G-AS1, MIR9-3HG, F11-AS1, and NNT-AS1 lncRNAs is caused by the hypo-methylation of the respective CpG sites cg23614229, cg00576773, cg23957912, and cg12626968."
35715447
sparser
"The cg23614229, cg23957912, and cg11052780 DMCs and the CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 DElncRNAs were identified as significant high-risk factors for the poor prognosis of PC patients."
35715447
sparser
"In the present study, we illuminated the role of CACNA1G-AS1 and the molecular mechanism between CACNA1G-AS1 and miR-205 in human keloid fibroblasts."
32495824
sparser
"m6A methylation of FTH1, which correlates with a poor cancer prognosis, is linked with CACNA1G-AS1 ."
39022677
sparser
"Consistent with above studies, we discovered that CACNA1G-AS1 level was significantly increased in keloid tissues and keloid fibroblasts."
32495824
sparser
"LncRNA CACNA1G-AS1 has been found to upregulate the expression of FTH1 through the IGF1BP2 axis, regulate ferritinophagy to suppress ferroptosis, and ultimately promoting the proliferation and migration of ovarian cancer cells ( xref )."
39210921
sparser
"CACNA1G-AS1 overexpression and knockdown exerted the opposite roles in proliferation, invasion and apoptosis of keloid fibroblasts, suggesting that CACNA1G-AS1 was closely related to progression of keloid fibroblasts."
32495824
sparser
"The establishment of a detailed understanding of DNA methylation-altered CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 lncRNAs in PC will facilitate the characterization of oncogenic lncRNAs."
35715447
sparser
"All of the above results revealed that lncRNA CACNA1G-AS1 enhanced proliferation and invasion and inhibited apoptosis by sponging miR-205 in human keloid fibroblasts."
32495824
sparser
"For example, the lncRNA CACNA1G-AS1 facilitates hepatocellular carcinoma progression via the miR-2392/C1orf61 pathway[ xref ]."
32351291
sparser
"Interestingly, miR-205 expression was oppositely correlated with CACNA1G-AS1 expression."
32495824
sparser
"The significant prognostic association of CACNA1G-AS1, F11-AS1, NNT-AS1, and MSC-AS1 lncRNAs suggests their association in PC progression which will shed light on the future development of lncRNA-based prognostic biomarkers specific for PC."
35715447
sparser
"Moreover, miR-205 level was down-regulated by CACNA1G-AS1."
32495824
sparser
"LncRNA CACNA1G-AS1 suppressed ferroptosis and promoted ovarian cancer progression by upregulating FTH1 expression [ xref ]."
39246507
sparser
"The data suggested that CACNA1G-AS1 might be a novel treatment target for keloids."
32495824
sparser
"CACNA1G-AS1 was highly expressed in keloid tissues and keloid fibroblasts, and CACNA1G-AS1 regulated proliferation, invasion, and apoptosis in keloid fibroblasts."
32495824
sparser
"CACNA1G-AS1 was predicted to interact with miR-205 and miR-205 expression was down-regulated by CACNA1G-AS1."
32495824
sparser
"These findings provided new evidence for the better understanding of CACNA1G-AS1 and a novel potential diagnostic target of keloid."
32495824
sparser
"Of them, three lncRNAs ( LINC00189 , CACNA1G-AS1 , and AC105384.1 ) seem to be risk factors, and the remaining two lncRNAs ( AL133467.1 and CHRM3-AS2 ) are protective factors."
33708773
sparser
"By bioinformatic analysis, Liang et al. constructed a coding–non-coding gene co-expression diagram, and found that 1731 lncRNAs constantly up-regulated and lncRNA CACNA1G-AS1 may be crucial for keloid formation [ xref ]."
33243301
sparser
"Finally, we performed multivariate Cox regression analysis for five optimal lncRNA biomarkers and constructed a lncRNA-based risk score model based on the linear combination of the expression of five optimal lncRNA biomarkers, weighted by their coefficients from the multivariate regression analysis as follows: EpiLncRNASig = (0.197) ∗ expression ( LINC00189 ) + (0.167) ∗ expression ( CACNA1G-AS1 ) + (−0.432) ∗ expression ( AL133467.1 ) + (−0.374) ∗ expression ( CHRM3-AS2 ) + (0.395) ∗ expression ( AC105384.1 )."
33708773
sparser
"As shown in xref , three lncRNAs ( LINC00189 , CACNA1G-AS1 , and AC105384.1 ) revealed significantly higher expression in the high-risk group compared to those in the low-risk group, and two lncRNAs ( AL133467.1 and CHRM3-AS2 ) are significantly upregulated in the low-risk group and down-regulated in the high-risk group ( xref )."
33708773
sparser
"By analyzing CACNA1G-AS1 expression levels in 122 pairs of non-small cell lung cancer (NSCLC) and normal tissue samples as well as in NSCLC cell lines, xref identified CACNA1G-AS1 as an oncogene to promote cell migration, invasion, and epithelial-mesenchymal transition via regulating HNRNPA2B1 ."
33708773
sparser
"A recent study performed by Wei revealed higher expression of CACNA1G-AS1 in colorectal cancer (CRC) tissues compared to adjacent normal tissues and found that CACNA1G-AS1 was able to enhance proliferative and invasive abilities of CRC cells by downregulating p53 via forming a carcinogenic complex with EZH2 ( xref )."
33708773
sparser
"Another recent study has reported that lncRNA CACNA1G-AS1 can act as competing endogenous RNAs (ceRNAs) to regulate miR-205 expression, and it promotes proliferation and invasion in human keloid fibroblasts ( xref )."
33708773
sparser
"Meanwhile, the expression levels of lncRNAs, including SNHG1 , MIR3142HG , CACNA1G-AS1 , and MIR155HG , were significantly down-regulated."
37569472
sparser
"LncRNA CACNA1G-AS1 facilitates hepatocellular 1637 carcinoma progression through the miR-2392/C1orf61 pathway."
33948587
sparser
"For example, research conducted about lncRNA-ATB suggested a signaling axis composition of ZNF217/TGF-β2/miR-200c/lncRNA-ATB, and there has also been an association reported between keloids and CACNA1G-AS1, HOXA11-AS, LINC00312 and other lncRNAs ( xref , xref )."
32309369
sparser
"CACNA1G-AS1 was identified as a carcinogenic lncRNA which contributed to accelerate the development of OC and lead to poor prognosis [ xref ]."
36187230
sparser
"Two additional ncRNAs were also shown to affect p53 levels: the lncRNA CACNA1G-AS1, which decreases p53 levels, is more highly expressed in CRC tissues than in adjacent normal tissue, whereas the circular RNA, circZNF609, which enhances p53 levels, shows decreased expression in CRC compared with adjacent normal tissue [ xref , xref ]."
33924934
sparser
"The study on aberrantly expressed lncRNAs in ALCL identified five lncRNAs, which were highly expressed in ALCL, including ~5, ~10, ~15, ~17, and ~19-fold for CACNA1G-AS1, BMS1P20, RNF144A-AS1, LINC01013, and MIR503HG, respectively. xref Among these, the function of LINC01013 has been validated in tumor cell invasion, however, no recent studies have reported an interaction between other lncRNAs and progression of ALCL. xref Pan et al identified 189 differentially expressed lncRNAs in FL compared to reactive lymphatic nodes tissues (>10 fold). xref ENST00000572608, ENST00000545410 (RP11-625 L16.3), and ENST00000433406 (CTC-546 K23.1) showed a significant high expression, suggesting their potential role in the pathogenesis of FL. xref Moreover, plenty of unknown lncRNAs, including AC00196.1, RP11-12A2.3, AF127936.5, AC010983.1, and RP11-530N7.3 has been identified in MCL, which needs their pathological role to be clear. xref "
35685474
sparser
"Other studies have shown that LncRNA CACNA1G-AS1 can upregulate the expression of FTH1 through the IGF2BP1 axis, thereby inhibiting ferroptosis by regulating FTH phagocytosis, and ultimately promoting the proliferation and migration of ovarian cancer cells ( xref )."
38550378
sparser
"For example, Zheng et al. conducted a prognostic signature in OC detection based on four m 6 A-modified lncRNAs AC010894.3, ACAP2-IT1, CACNA1G-AS1 and UBA6-AS1, but the specific functions and mechanisms of these lncRNAs have not been annotated [ xref ]."
37069649
sparser
"In a previous study, the expression of lncRNA CACNA1G-AS1 (CAS1) was confirmed abnormally high in keloid tissue, suggesting that CAS1 was involved in keloid formation [ xref ]."
33243301
sparser
"In comparison, the remaining six lncRNAs ( PCOLCE-AS1 , MEF2C-AS1 , LINC01558 , HOXB-AS2 , CACNA1G-AS1 and AC026904.1 ) and ten mRNAs ( ZCCHC24 , NBL1 , SLC22A3 , GFPT2 , LRRC17 , TCF15 , PTGIS , FSTL3 , PRDM6 and ARHGAP6 ) were positively associated with OS ( P < 0.05)."
33223503
sparser
"As a result, 11 lncRNAs, including C4A-AS1 , LINC02408 , AC087521.1 , LINC00488 , AC010275.1 , CHRM3-AS2 , LINC00337 , Z98257.1 , AC104667.2 , SOCS2-AS1 and CACNA1G-AS1 , were identified for modeling ( xref , xref )."
33223503
sparser
"Recently, Jin et al. (2023) reported that the lncRNA CACNA1G-AS1 inhibits ferroptosis and supports cancer cell proliferation and migration by modulating FTH1 expression and iron availability [ xref ]."
39061859
sparser
"To integrate establish an overall effective osteosarcoma scoring model, 4 epi-lncRNAs were removed according to stepAIC, and the remaining four epi-lncRNAs (A2M-AS1, CACNA1G-AS1, LBA2-AS1, and NNT-AS1) were recruited to build a risk model ( xref )."
35783605
sparser
"It can be observed that LBX2-AS1 has a significant positive correlation with a variety of immune infiltrating cells, such as Activated dendritic cell, Macrophage and Central memory CD8 T cell, and CACNA1G-AS1 has a significant negative correlation with a variety of immune infiltrating cells, such as Type 17 T helper cell, Immature dendritic cell and Activated dendritic cell ( xref )."
35783605
sparser
"The results showed that the expression of A2M-AS1, CACNA1G-AS1, LBA2-AS1, and NNT-AS1 was significantly lower in osteosarcoma cells U2OS and 143B compared with hFOB1.19 cells ( xref )."
35783605
sparser
"The long noncoding RNA (lncRNA) CACNA1G-AS1 was shown that it increases the growth, and migration of OC."
38544837
sparser
"CACNA1G-AS1 is highly expressed in colorectal cancer ( xref ) and hepatocellular carcinoma tissues ( xref ), which accelerates the malignant biological process of both cancers."
35783605
sparser
"Dual luciferase reporter assay was carried out to examine the relationship between CACNA1G-AS1 and miR-205 and RNA immunoprecipitation (RIP) assay was conducted to further confirm the relation."
32495824
sparser
"We constructed ovarian cancer cell models with different expression levels of CACNA1G-AS1 and IGF2BP1 and then performed WB to detect FTH1 and IGF2BP1 expression."
37304234
sparser
"Results: CACNA1G-AS1 level was up-regulated in keloid tissues and keloid fibroblasts."
32495824
sparser
"The results showed that in CACNA1G-AS1 knockdown ovarian cancer cells, FTH1 and IGF2BP1 expression significantly decreased, while IGF2BP1 overexpression reversed this change."
37304234
sparser
"Furthermore, a lncRNA-based risk score was developed by integrating the expression data for these 11 lncRNAs with corresponding coefficients weighted by the LASSO model as follows: Risk score = (0.147 × LINC02408 expression value) + (-0.066 × LINC00488 expression value) + (-0.161 × LINC00337 expression value) + (0.104 × Z98257.1 expression value) + (-0.129 × CHRM3-AS2 expression value) + (-0.14 × C4A-AS1 expression value) + (-0.156 × AC104667.2 expression value) + (0.088 × AC087521.1 expression value) + (-0.159 × SOCS2-AS1 expression value) + (0.096 × AC010275.1 expression value) + (0.111 × CACNA1G-AS1 expression value)."
33223503
sparser
"Interestingly, in vitro experiments in ovarian cancer have shown that lncRNA CACNA1G-AS1 can upregulate FTH1 expression via the IGF2BP1 axis and inhibit ferroptosis via the ferritinophagy pathway, which is a selective type of autophagy xref ."
39827294
sparser
"A previous study stated that lncRNA CACNA1G-AS1 controls the induction of ferritinophagy and suppression of ferroptosis by up-regulating FTH1 expression via the IGF2BP1 axis xref ."
39827294
sparser
"The overexpression of CACNA1G-AS1 in hepatocellular carcinoma patients was linked to a low survival rate [ xref ]."
33223503
sparser
"Of note, SOCS2-AS1 and CACNA1G-AS1 can act as a ceRNA to participate in tumorigenesis and development [ xref , xref ]."
33223503
sparser
"Further support for these findings was obtained by knocking down CACNA1G-AS1, which reduced OC tumorigenesis in vivo ."
38544837
sparser
"A mechanistic study showed that CACNA1G-AS1 upregulates FTH1 expression via the IGF2BP1 axis, inhibiting ferroptosis through ferritinophagy regulation ( xref )."
38544837
sparser
"Further bioinformation analysis revealeld that lncRNA CACNA1G-AS1 (CAS1), highly expressed in keloid tissue, may act crucial role in keloid formation."
36046343
sparser
"In vitro cell experiments showed that LncRNA CACNA1G-AS1 could up-regulate FTH1 expression through IGF2BP1 axis, thus inhibited ferroptosis by regulating ferritinophagy, and finally promoted proliferation and migration in ovarian cancer cells."
37304234
sparser
"Tumor-bearing mice studies showed that the knock-down of LncRNA CACNA1G-AS1 could inhibited the tumorigenesis of ovarian cancer cells in vivo condition."
37304234
sparser
"Our results demonstrated that LncRNA CACNA1G-AS1 could promote the malignant phenotypes of ovarian cancer cells through FTH1-IGF2BP1 regulated ferroptosis."
37304234
sparser
"LncRNA CACNA1G-AS1 can target IGF2BP1, thus regulating the expression of target mRNAs."
37304234
sparser
"Zheng confirmed that CACNA1G-AS1 is strongly linked to the methylation profile and clinical prognosis of ovarian cancer patients through bioinformatics analysis [ xref ]."
37304234
sparser
"The results confirmed that compared with ovarian cells and tissues, CACNA1G-AS1, IGF2BP1 and FTH1 expression levels were obviously increased in ovarian cancer samples ( xref , xref , xref )."
37304234
sparser
"Meanwhile, the expression of CACNA1G-AS1 in the cytoplasm was over 70%, which confirmed that CACNA1G-AS1 was mainly located in the cytoplasm of ovarian cancer cells ( xref ), indicating that this lncRNA might play its own role by regulating posttranscriptional RNA expression."
37304234
sparser
"IGF2BP1 targets CACNA1G-AS1 and FTH1."
37304234
sparser
"Microarray profiling of long noncoding RNAs (lncRNAs) has also been performed in lesional keloid tissue, identifying altered expression of CACNA1G-AS1 and HNF1A-AS1, which interact not only with pro-fibrotic TGF-β pathways, but also with cellular adhesion and tight junction signaling [ xref , xref ]."
33202590
sparser
"The results revealed that the contents of CACNA1G-AS1 and FTH1 in IGF2BP1 samples treated with AGO2 showed obvious enrichment compared with those treated with IgG, while the contents of CACNA1G-AS1 and FTH1 in AGO2 samples treated with IGF2BP1 were significantly enriched compared with those in samples treated with mimics-NC."
37304234
sparser
"The present study was aim to illuminate the mechanism of calcium voltage-gated channel subunit alpha1 G antisense RNA 1 (CACNA1G-AS1) in human keloid fibroblasts."
32495824
sparser
"All these results showed that the amount of CACNA1G-AS1 and FTH1 pulled down by the AGO2 antibody significantly increased in ovarian cancer cells transfected with IGF2BP1 ( xref and xref )."
37304234
sparser
"In colocalization analysis, we noticed that CACNA1G-AS1, FTH1 (green) and IGF2BP1 (red) colocalized in the cytoplasm of ovarian cancer cells ( xref )."
37304234
sparser
"Based on this, we concluded that IGF2BP1 could bind to CACNA1G-AS1 and FTH1."
37304234
sparser
"CACNA1G-AS1 promotes FTH1 expression by IGF2BP1-mediated m6A methylation."
37304234
sparser
"CACNA1G-AS1, CAS1."
36046343
sparser
"Methods: CACNA1G-AS1 and miR-205 levels were detected using quantitative real-time polymerase chain reaction (qRT-PCR)."
32495824
sparser
"LncRNA Calcium voltage-gated channel subunit alpha1 G antisense RNA 1 (CACNA1G-AS1, CAS1) is the antisense RNA of CACNA1G, mRNA of the T-type channel protein Cav3.1 ( xref )."
36046343
sparser
"The results revealed that the colocalization of autophagy regulator (LC3) and lysosome (LAMP2) significantly increased in CACNA1G-AS1 knockdown ovarian cancer cells, while IGF2BP1 upregulation reversed this change."
37304234
sparser
"First, we detected the colocalization of ferritin and lysosome labels, and the results confirmed that the colocalization of ferritin (FTH1) and lysosome (LAMP2) significantly increased in CACNA1G-AS1 knockdown ovarian cancer cells, while IGF2BP1 upregulation reversed this change."
37304234
sparser
"Moreover, miR-205 was targeted by CACNA1G-AS1 and miR-205 was markedly decreased in keloid tissues and keloid fibroblasts."
32495824
sparser
"According to these results ( xref – xref ), we concluded that CACNA1G-AS1 could inhibit ferritinophagy via IGF2BP1-mediated FTH1 methylation in ovarian cancer cells."
37304234
sparser
"The results showed that overexpressed CACNA1G-AS1 could upregulate FTH1 and GPX4, while IGF2BP1 downregulation could reverse this change ( xref and xref ); moreover, CACNA1G-AS1 knockdown could downregulate FTH1 and GPX4 expression, while IGF2BP1 upregulation could rescue this effect ( xref and xref )."
37304234
sparser
"Also, miR-205 expression was negatively regulated by CACNA1G-AS1 and miR-205 silencing enhanced proliferation and invasion and inhibited apoptosis."
32495824
sparser
"In CACNA1G-AS1 knockdown ovarian cancer cells, the ROS contents significantly increased, and these changes could be reversed by IGF2BP1 and FTH1 overexpression ( xref and xref )."
37304234
sparser
"Here, as an example, we describe in more detail the CACNA1G-AS1 module and its miRNAs, which have been experimentally validated."
37084275
sparser
"CACNA1G‐AS1 promoted the progression of HCC via competitively binding miR‐2392 and alleviating its inhibition on C1orf61. xref MCM3AP‐AS1 promoted the expression of FOXA1 through targeting miR‐194‐5p and thus exerted an oncogenic role in HCC. xref DSCR8 facilitated the activation of the Wnt/β‐catenin signaling pathway in HCC via the DSCR8/miR‐485‐5p/FZD7 axis. xref A few studies identified HCC‐related potential prognostic biomarkers via the construction of the ceRNA network. xref , xref , xref However, they were based on online tools that failed to take complex interactions among genes or disease‐specific data features into account."
33232580
sparser
"Furthermore, CACNA1G-AS1 and miR-205 played the antagonistic role in miR-205 expression, proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
sparser
"Genes in module CACNA1G-AS1 have lower expression levels in the Basal subtype when compared to the other subtypes in TCGA-BRCA and METABRIC ( xref ) and contribute to the biology of this subtype."
37084275
sparser
"These experimental results confirmed that CACNA1G-AS1 could inhibit ferroptosis in ovarian cancer cells through the IGF2BP1-FTH1 axis."
37304234
sparser
"CACNA1G-AS1 inhibits mitophagy through the IGF2BP1-FTH1 axis in ovarian cancer cells."
37304234
sparser
"Moreover, in CACNA1G-AS1 knockdown ovarian cancer cells, red fluorescence intensity was obviously reduced, while these changes could be rescued through IGF2BP1 and FTH1 overexpression ( xref and xref )."
37304234
sparser
"Conclusion: CACNA1G-AS1 suppressed miR-205 expression to promote proliferation and invasion and inhibit apoptosis in human keloid fibroblasts."
32495824
sparser
"Thus, we confirmed that CACNA1G-AS1 could maintain the stability of MMP in ovarian cancer cells through the IGF2BP1-FTH1 axis."
37304234
sparser
"In order to check whether we could exploit our modules to explain such changes, we further investigated the most frequent miRNAs in the CACNA1G-AS1 module ( xref ) and checked their expression in the TCGA-BRCA dataset."
37084275
sparser
"The observation of mitochondrial morphology revealed that in CACNA1G-AS1 knockdown ovarian cancer cells, the mitochondrial volume was obviously reduced, the mitochondrial membrane was ruptured and the cristae vanished, while these changes could be rescued by IGF2BP1 and FTH1 overexpression ( xref )."
37304234
sparser
"The above results confirmed that CACNA1G-AS1 could inhibit mitophagy in ovarian cancer cells through the IGF2BP1-FTH1 axis."
37304234
sparser
"CACNA1G-AS1 promoted the proliferation, migration and in vivo tumorigenesis of ovarian cancer cells through the IGF2BP1-FTH1 axis."
37304234
sparser
"Colony formation assays confirmed that the number of newly generated cells in the CACNA1G-AS1 overexpression group obviously increased, while this number correspondingly decreased after IGF2BP1 and FTH1 inhibition in ovarian cancer cells ( p < 0.01, xref and xref )."
37304234
sparser
"EdU assays showed that the proportion of new cells in the CACNA1G-AS1 overexpression group obviously increased ( p < 0.01), while this proportion correspondingly decreased after IGF2BP1 and FTH1 inhibition in ovarian cancer cells ( p < 0.01, xref and xref )."
37304234
sparser
"It has been proposed that plenty of lncRNAs were closely related to the progression of keloid fibrosis [ xref ], such as HNF1A-AS1 [ xref ], COL1A2-AS1 [ xref ], CACNA1G-AS1, HOXA11-AS, LINC00312, and RP11-91I11.1 [ xref ]."
32495824
sparser
"All these results indicated that CACNA1G-AS1 could promote cell proliferation through the IGF2BP1-FTH1 axis in ovarian cancer cells."
37304234
sparser
"These results confirmed that CACNA1G-AS1 could promote cell migration through the IGF2BP1-FTH1 axis in ovarian cancer cells."
37304234
sparser
"The subcutaneous tumor transplantation experiment showed that compared with that in tumor-bearing mice treated with SKOV3 cells and FAC, the growth rate of tumors in vivo significantly slowed ( xref ), while the tumor weight and volume were obviously reduced ( p < 0.01, xref and xref ) in tumor-bearing mice injected with CACNA1G-AS1 knockdown SKOV3 cells and FAC."
37304234
sparser
"The above results indicated that CACNA1G-AS1 may decrease the ferroptosis sensitivity of ovarian cancer cells in vivo ."
37304234
sparser
"Zheng et al. screened 4 lncRNAs that are strongly linked to the methylation and clinical prognosis of ovarian cancer patients (AC010894.3, ACAP2-IT1, CACNA1G-AS1 and UBA6-AS1) through bioinformatics analysis."
37304234
sparser
"In contrast, in CACNA1G-AS1 knockdown ovarian cancer cells, the ROS and Fe 2+ contents significantly increased, while these changes could be reversed by IGF2BP1 and FTH1 upregulation ( xref and xref )."
37304234
sparser
"Recent study demonstrated that calcium voltage-gated channel subunit alpha1 G antisense RNA 1 (CACNA1G-AS1) was up-regulated in keloid and had a positive effect on cell migration in keloid fibrosis [ xref ]."
32495824
sparser
"Previous studies showed that CACNA1G-AS1 could promote proliferation in hepatoma cells through the miR-2392/C1orf61 axis, and this lncRNA could also regulate the malignant phenotype of non-small cell lung cancer via the HNRNPA2B1 pathway [ xref – xref ]."
37304234
sparser
"However, the expression and function of lncRNA CACNA1G-AS1 remain unclear in human keloid fibroblasts up to date."
32495824
sparser
"Cell model tests revealed that CACNA1G-AS1 could upregulate FTH1 through IGF2BP1-mediated m6A methylation."
37304234
sparser
"However, there is no relevant study on the interaction between CACNA1G-AS1 and miR-205 in keloid fibroblasts."
32495824
sparser
"In the present study, we explored the relationship between CACNA1G-AS1 and miR-205 and further studied their effects on proliferation, invasion, and apoptosis of keloid fibroblasts."
32495824
sparser
"Huang et al. also discovered that A2M-AS1, CACNA1G-AS1, LBX2-AS1, and NNT-AS1 lncRNA molecules were downregulated in OS cell lines and happened to be associated with a good prognosis in patients with OS."
37371065
sparser
"Cell function experiments confirmed that CACNA1G-AS1 could inhibit mitophagy and promote malignant phenotypes in ovarian cancer cells through IGF2BP1-mediated FTH1 m6A methylation."
37304234
sparser
"In vivo studies confirmed that CACNA1G-AS1 knockdown could increase the sensitivity of ovarian cancer cells to ferroptosis induced by Fe 2+ overload."
37304234
sparser
"Ten m6A-related lncRNAs prognostic signature (AC004816.1, AC013270.1, AL138820.1, AC008669.1, AC010336.1, AC097376.3, AC130710.1, ACAP2-IT1, AL138820.1 and CACNA1G-AS1) was selected according to the optimal λ value of tenfold cross-validation (Fig.  xref A and B)."
35676619
sparser
"CACNA1G-AS1 was highly expressed in keloid tissues and keloid fibroblasts."
32495824
sparser
"A seven m6A-related lncRNAs prognostic signature (AC008669.1, AC010336.1, AC097376.3, AC130710.1, ACAP2-IT1, AL138820.1 and CACNA1G-AS1) was obtained."
35676619
sparser
"First, qRT-PCR was conducted to detect the expression level of CACNA1G-AS1 in normal skin tissues, keloid tissues, normal fibroblasts, and keloid fibroblasts."
32495824
sparser
"This research confirmed that CACNA1G-AS1 is obviously upregulated in ovarian cancer samples and could upregulate FTH1 through IGF2BP1-mediated m6A methylation."
37304234
sparser
"CACNA1G-AS1 inhibits ferroptosis, promotes malignant phenotypes and increases sensitivity to ferroptosis in ovarian cancer cells through IGF2BP1-FTH1-mediated ferritinophagy inhibition."
37304234
sparser
"Jianfeng Zheng etc. conduct a four m6A-related lncRNAs prognostic signature (AC010894.3, ACAP2-IT1, CACNA1G-AS1 and UBA6-AS1) for predicting the prognosis of OC patients based on the training dataset, while we built a m6A-related lncRNAs prognostic signature containg seven lncRNAs."
35676619
sparser
"Compared with the normal skin tissues, CACNA1G-AS1 expression was noticeably elevated in keloid tissues ( n =20) ( xref A)."
32495824
sparser
"A recent study established a risk model based on four lncRNAs that are involved in m 6 A regulation (AC010894.3, ACAP2-IT1, CACNA1G-AS1, and UBA6-AS1)."
35585970
sparser
"ACAP2-IT1 and CACNA1G-AS1 was included in the m6A-related lncRNAs prognostic signature of two analyses."
35676619
sparser
"Superior to our analysis is that they further analyzed the differences of immune cell infiltration and chemotherapy drugs between high-and low- risk groups as well as the effect of CACNA1G-AS1 on ovarian cancer cell proliferation."
35676619
sparser
"A seven m6A-related lncRNAs prognostic signature (AC008669.1, AC010336.1, AC097376.3, AC130710.1, ACAP2-IT1, AL138820.1 and CACNA1G-AS1) was conducted for predicting the prognosis of OC."
35676619
sparser
"LncRNA CACNA1G-AS1 was identified to be upregulated in 30 OC specimens and 3 OC cell lines, while its knockdown restrained the multiplication capacity of OC cells ( xref )."
35003214
sparser
"QRT-PCR assay showed that CACNA1G-AS1 expression was greatly increased by CACNA1G-AS1 and was sharply inhibited by the interference of CACNA1G-AS1 ( xref A)."
32495824
sparser
"Then the results of CCK-8 assay suggested that overexpression of CACNA1G-AS1 notably promoted the proliferation of keloid fibroblasts and the silence of CACNA1G-AS1 had the opposite effect on proliferation with CACNA1G-AS1 overexpression ( xref B)."
32495824
sparser
"Besides, transwell assay demonstrated that the number of invaded keloid fibroblasts was significantly increased in CACNA1G-AS1 transfected keloid fibroblasts, which was decreased by CACNA1G-AS1 silencing ( xref C)."
32495824
sparser
"Moreover, the apoptosis of keloid fibroblasts was markedly inhibited by CACNA1G-AS1 overexpression and was promoted by the transfection with si-CACNA1G-AS1 ( xref D)."
32495824
sparser
"The result revealed that CACNA1G-AS1 significantly reduced caspase-3 activity and silenced CACNA1G-AS1 promoted caspase-3 activity ( xref E)."
32495824
sparser
"According to the least absolute shrinkage and selection operator (LASSO) Cox regression analysis of these ten lncRNAs, they then conducted a prognostic signature containing four m 6 A-mediated lncRNAs (AC010894.3, ACAP2-IT1, CACNA1G-AS1 and UBA6-AS1), which shows great predictive value in ovarian cancer detection [ xref ]."
37069649
sparser
"These data revealed that CACNA1G-AS1 participated in the regulation of proliferation, invasion, and apoptosis of keloid fibroblasts in vitro ."
32495824
sparser
"CACNA1G-AS1 directly interacted with miR-205."
32495824
sparser
"As documented, a risk model based on 4 lncRNAs (CACNA1G-AS1, ACAP2-IT1, AC010894.3 and UBA6-AS1) involved in m6A regulation was identified to predict OS and therapeutic value in OC independently [ xref ]."
37674251
sparser
"Next, the potential targets of CACNA1G-AS1 were predicted using LncBase Predicted v."
32495824
sparser
"The putative binding sites between CACNA1G-AS1 and miR-205 and the mutant sequences of CACNA1G-AS1 were shown in xref A. Subsequently, to determine the interaction between them, luciferase reporter vectors were co-transfected into keloid fibroblasts with miR-205 or miR-NC."
32495824
sparser
"Long non-coding RNA (lncRNA) CACNA1G-AS1 promotes the expression of hnRNPA2B1 in non-small cell lung cancer (NSCLC) cell lines, inducing malignant cell invasion, migration, and epithelial-mesenchymal transformation (EMT) ( xref )."
33505405
sparser
"Additionally, Y Song et al. established a nomogram based on the expression level of seven m 6 A-related lncRNAs (AC008669.1, AC010336.1, AC097376.3, AC130710.1, ACAP2-IT1, AL138820.1 and CACNA1G-AS1) to predict survival rate of patients with ovarian cancer, revealing that m 6 A-related lncRNAs may act an important role in ovarian cancer treatment [ xref ]."
37069649
sparser
"JIN et al. found that LncRNA CACNA1G-AS1 can stimulate the growth and transfer of ovarian cancer cells through the FTH1-IGF2BP1 axis to regulate the expression of FTH1 and inhibit ferritinophagy ( xref )."
39192972