IndraLab

Statements


Ply activates CYLD. 4 / 4
| 4

reach
"CYLD is also highly induced by pneumolysin (PLY)."

reach
"CYLD is highly induced by Streptococcus pneumoniae pneumolysin (PLY)."

reach
"CYLD was highly induced by PLY and it inhibited MKK3-p38 induced expression of PAI-1 in the lung potentiating ALI [XREF_BIBR, XREF_BIBR]."
| PMC

reach
"Specifically, PLY induces the protein cylindromatosis (CYLD), which de-ubiquitinates TAK1, an activator of MKK3, resulting in inhibition of p38 signaling."