IndraLab

Statements

MIB2 inhibits CYLD. 4 / 6
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"The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD."
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"Mib2 can enhance NF-kappaB signaling in inflammatory response by promoting ubiquitin dependent CYLD degradation in the Notch pathway."
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"Together, these results suggest that MIB2 enhances NF-kappaB signaling in inflammation by promoting the ubiquitin dependent degradation of CYLD."
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"Here, using the cell-free based AlphaScreen and pulldown assays to detect protein protein interactions, along with immunofluorescence assays and murine Mib2-knockout cells and animals, we demonstrate that MIB2 promotes proteasomal degradation of CYLD and enhances NF-kappaB signaling."
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