IndraLab

Statements

USP22 binds KAT2A. 13 / 27
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"Gcn5 is closely associated with USP22 or its fly orthologue, Nonstop ( xref ; xref ; xref ; xref )."
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"This raises the hypothesis that once USP22 associates with SAGA and GCN5, it may oppose telomere recombination in APBs by promoting the binding of POT1 to telomeres via TRF1, thereby inhibiting ATR activation."
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"GCN5 binds to ubiquitin-specific peptidase 22 (USP22) which deubiquitinates and thus salvages the telomeric repeat-binding factor 1 (TRF1) shelterin protein."
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"There were 408 overlapping putative target genes bound by both USP22 and GCN5."
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"Motif analysis showed that the sequences bound by USP22 and GCN5 shared two common motifs."
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"Of these genes, 408 genes were bound potentially by both USP22 and GCN5, which accounted of 16.8% of genes recognized by USP22 and 18.1% recognized by GCN5 ( xref )."
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"The polypeptide composition of these purified complexes was assessed by silver staining, which revealed a pattern of 10-12 comigrating proteins shared by the USP22 and hGCN5 complexes."
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"Normalized ChIP‐seq signals for the individual SAGA subunits demonstrated inducible binding of GCN5, USP22, and ATXN7L3 after treatment (Fig 1C)."
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"We found either USP22 antibody or GCN5 antibody precipitated a large number of DNA fragments, indicating that either USP22 or GCN5 widely interacted with different genes in the genome of HeLa cells."
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"MACS analysis indicated that there were many genes potentially bound by USP22 or GCN5."
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"However, there are only a small part of genes bound by both USP22 and GCN5, indicating that the target genes regulated by USP22 and GCN5 were not completely the same."
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"This also explains that USP22 or GCN5 bound to different sites in the genome."
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"In addition to these motifs, there was no similar motif between USP22 and GCN5 binding sites.The USP22 and GCN5 binding sites had similar distributions across the whole genome."
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