IndraLab

Statements

EGF binds EGFR and ERBB4. 6 / 6
| 6
sparser
"It exerts its effects by binding to cell-surface EGF receptors (EGFR) ErbB1 and ErbB4 [ xref , xref ] and to the HB-EGF-specific receptor Nardilysin (Nrdc) [ xref , xref ]."
24888839
sparser
"The EGF-like ligands include EGF, amphiregulin, and transforming growth factor alpha (TGFα), which only bind to the EGF receptor (EGFR), and heparin binding EGF (HB-EGF), betacellulin, and epiregulin, which bind to both EGFR and ErbB4."
21381079
sparser
"This is the first report to identify the solution structure of the EGF-family ligand monomers that interact with both ErbB-1 and ErbB-4."
12074582
sparser
"Complementing these receptors is a family of ligands: e.g. EGF and transforming growth factor-α (TGF-α) bind only to ErbB1 (EGFR), heparin-binding EGF (HB-EGF) binds to both ErbB1 and ErbB4, and neuregulin 1 (NRG1) which binds to ErbB3 and ErbB4."
34354180
sparser
"EREG (epiregulin) belongs to the EGF growth factor family that binds both ERBB1 and ERBB4."
15743511
sparser
"Heparin-binding EGF like growth factor (HB-EGF) is an EGF family member, which interacts with EGFR and ERBB4 [ xref ]."
30738642