IndraLab

Statements

USP28 is phosphorylated on S714. 7 / 7
1 | 6
sparser
"Emerging literature suggests that the phosphorylation of USP28 at serine 67 and serine 714 by various kinases enhances its enzymatic activity xref ."
41041071
sparser
"In response to IR, USP28 becomes phosphorylated on Ser 67 and Ser 714 in an ATM-dependent manner [ xref ]."
21480003
sparser
"Upon DNA damage, the phosphorylation of USP28 on serine 67 and serine 714 by the kinase ATM increases its enzymatic activity [ xref ]."
| PMC
sparser
"As previously indicated, it has been proved that phosphorylation of USP28 on serine 67 and serine 714 increases its enzymatic activity upon DNA damage [ xref ]."
| PMC
hprd
No evidence text available
17525332
sparser
"Our results show that, under these conditions, ATM/ATR-mediated phosphorylation of USP28 at S67 and S714 [ xref , xref ] protects it from DYRK2-mediated degradation, allowing USP28 to stabilize DYRK2 and promote p53 phosphorylation at S46, crucial for apoptosis [ xref ]."
40858801
sparser
"Considering the phosphorylation of USP28 on serine 67 and serine 714 regulates its enzymatic activity, it could be also possible to develop drugs targeting the phospho-sites."
| PMC