IndraLab

Statements

KCNMA1 binds NKβ1. 5 / 5
| 5
sparser
"We have observed that Slo1 and NKα subunits interact with different regions on NKβ1 (see [ xref ] for NKα binding sites), and it is possible that NKβ1 can interact with Slo1 and NKα simultaneously."
19729011
sparser
"The possible existence of Slo1-NKβ1 interaction within a larger complex is intriguing in light of growing evidence that Na + /K + -ATPases can function as transducers for signaling pathways [ xref - xref ]."
19729011
sparser
"The region of NKβ1 that interacts with Slo1 is highly conserved in all known Na + /K + -ATPase and H + /K + -ATPase β-subunits [ xref ]."
19729011
sparser
"In morphologically polarized cells such as neurons and epithelial cells, the interaction between Slo1 and NKβ1 may be responsible for targeting of BK Ca channels to specific regions on the plasma membrane."
19729011
sparser
"We cannot exclude that the interaction between NKβ1 and BK Ca channels may be facilitated by the presence of NKα subunits, or that the Slo1-NKβ1 interaction occurs within a larger complex formed between Na + /K + -ATPase, BK Ca channels, and other proteins."
19729011