IndraLab

Statements

USP2 activates epithelial to mesenchymal transition. 5 / 5
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"It has been demonstrated that the TGF-β pathway has an effective role in metastasis; for instance, USP2 promotes EMT after interacting with TGFBR1 and TGFBR2 after TGF-β stimulation[76]."
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"Likewise, ubiquitin-specific peptidase 2 (USP2) downregulates the NF-κB pathway, inhibiting EMT in clear cell renal cell carcinoma metastasis (Duan et al., 2022)."
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"USP2 overexpression promoted proliferation and metastasis, and induced the EMT in CM cells in vitro, while specific inhibition of USP2 by ML364 produced the opposite effects."
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"In addition , USP2 activates Bmi1 and EMT by stabilizing Twist through removing ubiquitylation mediated by beta-transducin repeats-containing proteins ( beta-TrCP ) , a cellular E3 ubiquitin ligase ( 104 ) ."
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"In addition, USP2 activates Bmi1 and EMT by stabilizing Twist through removing ubiquitylation mediated by beta-transducin repeats containing proteins (beta-TrCP), a cellular E3 ubiquitin ligase."
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