IndraLab

Statements

ATXN3L activates KLF5. 5 / 11
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"To further determine whether ATXN3L increases the KLF5 protein stability, we measured the KLF5 protein half-lives by the cycloheximide (CHX) chase assays [XREF_BIBR]."
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"As expected, ATXN3L over-expression blocked the KLF5 protein degradation induced by WWP1 and FBW7."
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"To test whether ATXN3L can antagonize E3 ligase mediated KLF5 degradation, we transfected WWP1, Myc-FBW7, KLF5 and ATXN3L into HEK293FT cells."
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"To further confirm whether ATXN3L knockdown decreases KLF5 protein stability in human breast cancer cells, we knocked down ATXN3L in HCC1806 and SUM1315 (two basal type triple negative breast cancer cell lines), in which KLF5 is highly expressed."
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"Collectively, these results suggest that ATXN3L is a specific DUB for KLF5 and that ATXN3L increases KLF5 protein stability through deubiquitination."
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