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OTUB1 increases the amount of PGK1. 5 / 5
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"When H1299 cells were treated with the proline hydroxylase inhibitors, DMOG or FG4592 [70], overexpression of OTUB1 still promoted expression of PDK1, PGK1 or BNIP3 (Fig. 3A–D)."
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"Overexpression of OTUB1 enhanced expression of PDK1, PGK1, LDHA, VEGF, and PKM2 in VHL H1299 cells (Fig. 3G)."
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"In FIH-deficient HEK293T cells (Fig. 3H), overexpression of OTUB1 still enhanced expression of PDK1, PGK1 and GLUT1 under hypoxia (1% O ) (Fig. 3I–K)."
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"Overexpression of OTUB1 in H1299 cells enhanced expression of PGK1, LDHA, VEGF and BNIP3 under hypoxia (1% O ) as revealed by quantitative real-time PCR assays (qPCR) (Fig. 1A–D, S3F) [20, 67]."
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"However, reconstitution of OTUB1 in OTUB1 H1299 cells promoted expression of PDK1, PGK1, GLUT1 and LDHA compared to reconstitution of empty vector control under hypoxia (1% O ) (Fig. S4A–D, H)."
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