IndraLab

Statements

USP4 increases the amount of CTNNB1. 6 / 6
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"USP4 increased the level of beta-catenin by inducing its deubiquitinylation."
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"To verify that USP4 induces EMT process by upregulating beta-catenin expression, we checked the expression level of ZEB1 and E-cadherin in USP4 overexpressing PC14PE6 cells (XREF_FIG)."
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"As expected, knockdown of USP4 significantly downregulated the expression of beta-catenin (XREF_FIG) and suppressed the invasiveness of PC14PE6 and LvBr5-Luc cells (XREF_FIG)."
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"beta-Catenin protein stability was significantly lower in USP4 silenced PC14PE6 and LvBr4 cells than in PC14PE6 cells (XREF_FIG), demonstrating that USP4 positively regulated beta-catenin expression in metastatic lung cancer cells."
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"Knockdown of USP4 reduces the level of β-catenin protein without affecting the level of mRNA expression."
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"Based on the above results, we found that beta-catenin was involved in the metastatic potential of PC14PE6 and LvBr4 cells and that USP4 upregulated the expression of beta-catenin by deubiquitinylating beta-catenin."
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