IndraLab

Statements

JNK-IN-8 inhibits MAPK8. 7 / 7
3 | 1 3
eidos
"Importantly , our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2C116S expression ( and intact JNK2 signaling ) contributes to tumor progression ."
31063355
reach
"The result that JNK1 inhibition by JNK-IN-8 is important for synergy with lapatinib is not surprising considering that JNK-IN-8 was shown to have greater activity toward purified, recombinant JNK1 in vitro [XREF_BIBR]."
29285221
reach
"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."
23438744
tas
No evidence text available
25415535
tas
No evidence text available
22621397
tas
No evidence text available
27996267
reach
"Importantly, our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2 C116S expression (and intact JNK2 signaling) contributes to tumor progression."
31063355