IndraLab

Statements

JNK-IN-8 inhibits MAPK8. 7 / 7
3 | 1 3
eidos
"Importantly , our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2C116S expression ( and intact JNK2 signaling ) contributes to tumor progression ."
31063355
reach
"The result that JNK1 inhibition by JNK-IN-8 is important for synergy with lapatinib is not surprising considering that JNK-IN-8 was shown to have greater activity toward purified, recombinant JNK1 in vitro [XREF_BIBR]."
29285221
tas
No evidence text available
22621397
tas
No evidence text available
27996267
reach
"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."
23438744
reach
"Importantly, our data strongly suggest that concomitant inhibition of JNK1 by JNK-IN-8 in the context of JNK2 C116S expression (and intact JNK2 signaling) contributes to tumor progression."
31063355
tas
No evidence text available
25415535