IndraLab

Statements

OTUB1 inhibits UBE2E1 autoubiquitination. 3 / 3
| 3
eidos
"We show that OTUB1 suppresses UBE2E1 autoubiquitination in vitro and in cells , thereby preventing UBE2E1 from being targeted to the proteasome for degradation ."
30282802
eidos
"We show here that OTUB1 noncatalytically inhibits UBE2E1 autoubiquitination in vitro in either the presence or absence of E3 ligase ( Fig. 4 ) ."
30282802
eidos
"OTUB1 inhibits UBE2E1 autoubiquitination In previous studies in which OTUB1 has been shown to stabilize a substrate through its noncatalytic activity , OTUB1 inhibits the activity of an E2 that conjugates Lys-48-linked polyubiquitin to the substrate ( 21-26 ) ."
30282802