IndraLab

Statements

OSM binds OSMR and IL6ST. 4 / 5
1 | 4
sparser
"Following OSM binding to OSMR and gp130, JAK2 is phosphorylated, which in turn phosphorylates STAT3 permitting nuclear translocation and modulation of gene expression [ xref , xref , xref ]."
21481226
sparser
"The OSMR forms heterodimers with gp130 to bind OSM."
23880850
sparser
"Typically, OSM binding to the OSMR:gp130 complex causes the phosphorylation and activation of both STAT1 and STAT3 via JAK1/2 ( xref , xref ) which in turns leads the transcription of a large range of genes that include suppressor of cytokine signaling (SOCS)-3."
30899259
sparser
"It has been previously shown that OSM binding to the OSMR-β/gp130 receptor complex results in phosphorylation of tyrosine residues of the gp130 receptor; this triggers the recruitment, phosphorylation, and activation of STAT proteins, mainly STAT1, STAT3, and STAT5 [ xref – xref ]."
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