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USP7 activates SHH. 4 / 4
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"To further validate that Usp7 promotes MB cell proliferation and migration through activating Shh pathway, we carried out some rescue assays."
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"Taken together, these results illustrate that Usp7 promotes the proliferation and migration of MB cells through stimulating Shh pathway.Given that Usp7 promotes MB cell proliferation and metastasis, a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We provided both loss-of-function and gain-of-function evidence that Usp7 activates Shh pathway, not P53 pathway, culminating in MB cell growth and migration ( Fig. 4 D)."
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"The Gli-luciferase reporter assays in NIH3T3 cells and Sufu -/- MEF cells indicated that HAUSP positively regulated Shh pathway downstream of Sufu and at levels of Gli proteins (XREF_FIG)."
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