IndraLab

Statements

USP4 activates TGFB1. 3 / 4
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"Western blot analyses showed that the TbetaR-1 expression was significantly increased in HPMCs treated with TGF-beta1 and Flag-Akt, whereas no change was seen in cells treated with Smurf2 siRNA or USP4 siRNA."
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"Further studies demonstrated that USP4 mediated TGF-beta1 activation not only enhances the phosphorylation of Smad2 through TGF-beta, but also directly upregulate matrix metalloproteinase (MMP)-9-mediated cell migration and invasion of breast cancer cells."
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"Three examples of deubiquitinating enzymes for TbetaR-I are ubiquitin specific peptidase-4 (USP4), -11 (USP11) and -15 (USP15), all of which antagonize the effect of SMAD7 and strongly induce TGF-beta1 signalling [XREF_BIBR]."
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