IndraLab

Statements

OTUD7B inhibits Hypertrophy. 6 / 6
| 6
reach
"Histological examinations using H&E (Fig. 2G), WGA (Fig. 2H), Masson (Fig. 2J, K), and Sirius Red staining (Fig. 2L, M) consistently indicated that OTUD7B knockdown significantly intensified pressure overload-induced cardiac hypertrophy and fibrosis."
40158182
reach
"Furthermore, OTUD7B deficiency exacerbated transverse aortic coarctation surgery-induced myocardial hypertrophy, abnormal cardiac function, and fibrosis."
38084712
reach
"In cardiac myocytes, OTUD7B knockdown promoted phenylephrine stimulation-induced myocardial hypertrophy, whereas OTUD7B overexpression had the opposite effect."
38084712
reach
"Our animal experiments revealed that Cezanne overexpression in mice reversed DOX-induced cardiomyocyte apoptosis, autophagy, oxidative stress and hypertrophy."
36639017
reach
"Collectively, these findings demonstrate that OTUD7B knockdown exacerbates pressure overload-induced myocardial hypertrophy and fibrosis, leading to deteriorated cardiac function."
40158182
reach
"OTUD7B knockdown causes a reprogramming of fatty acid metabolism in pathological cardiac hypertrophy."
40158182