IndraLab

Statements

COPS5 activates JUN. 12 / 15
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"When transfected into HeLa cells, p38 (JAB1) potentiates the transcriptional activity of c-Jun, but co-transfection with rLHR prevents this effect."
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"Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1."
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"In addition, VDUP1 inhibited JAB1 mediated activator protein-1 activation and cell proliferation."
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"Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun."
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"Furthermore, Jab1 mediated PAR-2-induced c-Jun activation, which was followed by increased activation of activator protein-1."
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"Overexpression of CSN5 can not rescue c-Jun destabilization in siCSN1."
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"Human JAB1 (Jun activation domain binding protein 1) was first described as a coactivator of c-Jun and Jun D. JAB1 enhances the ability of c-Jun and Jun D to activate transcription by stabilizing comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Human JAB1 (Jun activation domain binding protein 1) was first described as a coactivator of c-Jun and Jun D. JAB1 enhances the ability of c-Jun and Jun D to activate transcription by stabilizing comp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For instance, JAB1 enhances c-Jun transactivation by enhancing binding to their cognate DNA sequences [39,40]."
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"COPS5 (official gene symbol of CSN5) is responsible for the deneddylation activity of the COP9 signalosome, and also known as Jab1 to activate c-Jun (Jun-activating and binding protein)."
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"CSN5 enhances AP-1-mediated transcriptional activation by stabilizing complexes of the transcription factors c-Jun or JunD [9]."
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"Jab1 and CSN5 can specifically stabilize the protein-DNA complexes on the off-rate of c-Jun and JunD with its cognate AP-1 DNA binding sites and potentiate c-Jun transactivation; however, Jab1 and CSN5 does not affect JunB or v-Jun binding [XREF_BIBR]."
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