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Nitric oxide inhibits EIF2AK1. 6 / 6
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"We additionally show that micromolar NO can fully reverse the inhibition of HRI by Hg 2+ , but not other metal cations."
17689536
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"Accordingly, we propose that protein synthesis is upregulated in cells contaminated with Hg 2+ as a result of Hg 2+ –thiol complex formation in HRI, which is reversed or reduced by NO due to the gener[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17689536
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"NO acts as an activator of HRI and CO serves as a suppressor of NO induced HRI activation XREF_BIBR."
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"NO acts as an activator of HRI [XREF_BIBR, XREF_BIBR, XREF_BIBR], while CO serves as a suppressor of NO induced HRI activation [XREF_BIBR]."
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"We examined the effects of NO on metal cation-induced inhibition of HRI."
17689536
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"It was proposed that NO * reverses Hg 2+ inhibited HRI by nitrosylating Cys409, likely to form a thiol adduct, S-NO in active site (XREF_FIG)."
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