IndraLab

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USP8 inhibits cell population proliferation. 18 / 18
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"We also observed that down-regulation of USP8 inhibited the proliferation of GC cells which highly expressed HER-3."
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"These chalcone derivatives effectively inhibit the activity of DUB, such as USP5, UCH-L3, USP2, UCH-L1, and USP8, leading to irreversible cell cycle arrest in breast, ovarian, and cervical cancer cells (IC50 = 1.5-12.5 µM), as well as inhibiting their proliferation and initiating apoptosis."
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"Down-Regulation of USP8 Inhibits Proliferation of Gastric Cancer Cells."
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"These results indicated that knockdown of USP8 arrested the cell cycle progression, thereby inhibiting cell proliferation."
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"Moreover, down-regulation of USP8 could promote the apoptosis of HER3 positive GC cells and inhibit the proliferation of them by affecting the cell-cycle."
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"Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation [Corrigendum]."
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"USP8 inhibited the migration and proliferation of HER-2 positive gastric cancer cells through the PI3K/AKT signaling pathway [31]."
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"Down-regulation of USP8 inhibits HER-3 positive GC cells proliferation in vivo and in vitro, which indicate that USP8 represents a feasible choice as a therapeutic target for HER-3 positive GC cells."
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"Therefore, it was confirmed that down-regulation of USP8 could inhibit the proliferation of NCI-N87, MKN-45 and AGS cell lines, which is HER-3 positive GC cells."
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"Targeting USP8 inhibits the proliferation of HCC and induces cell ferroptosis."
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"XREF_BIBR, XREF_BIBR Therefore, it can be inferred that down-regulation of USP8 may inhibit the proliferation and even metastasis of GC through this pathway."
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"USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K and AKT Signaling Pathway."
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"Both GADD45beta and CABLES1 may be responsible, at least in part, for the USP8 induced suppression of corticotroph tumor cell proliferation."
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"Down-Regulation of USP8 Suppresses HER-3 Positive Gastric Cancer Cells Proliferation."
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"In conclusion, USP8 inhibitor could inhibit proliferation, abolishes clonogenic ability, and induces apoptosis in pituitary corticotroph tumor cell-AtT20 cells."
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"All these results indicated that down-regulation of USP8 could inhibit the proliferation of HER-3 positive cells, NCI-N87 and MKN-45, in vivo."
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"The USP8 inhibited HER-2 positive GC cell proliferation and migration in vivo and in vitro and probably served as a novel potential therapeutic biomarker for HER-2 positive GC."
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"All in vitro results demonstrated that down-regulation of USP8 inhibited the proliferation and viability of GC cells with high expression of HER3 (NCI-N87, MKN-45 and AGS), but did not affect HER3 negative cells (MGC-803)."
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