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USP2 deubiquitinates CTNNB1. 3 / 3
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"Xu et al. found 29 that the expression of the deubiquitinating enzyme USP2 was elevated in angiotensin II-induced cardiac fibroblasts, and that its interaction with β-catenin prevented β-catenin deubiquitination from being degraded, thereby promoting the activation, proliferation, and collagen synthesis of cardiac fibroblasts."
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"Additionally, USP2-induced Wnt/beta-catenin signalling pathway activation via deubiquitination of beta-catenin protein."
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"The deubiquitinating enzyme USP2 interacts with β-catenin to deubiquitinate β-catenin without degradation, which in turn activates Wnt/β-catenin signaling 29."
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