IndraLab

Statements

Amsacrine inhibits KCNH2. 3 / 7
2 1 1 | 3
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"There is no data for I inhibition with the latter, but amsacrine blocked hERG channels in the open and inactivated states and its binding required a common drug receptor site within the pore-S6 region [14]."
37111245
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"3 Amsacrine blocked HERG currents in HEK 293 cells and Xenopus oocytes in a concentration dependent manner, with IC50 values of 209.4 nm and 2.0 microm, respectively."
15148258
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"HERG current block by amsacrine was not frequency dependent."
15148258