IndraLab

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TNFAIP3 inhibits MTOR. 11 / 11
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"As mTOR is a major negative regulator of autophagy, we hypothesized that TNFAIP3 could inhibit mTOR signaling for the introduction of autophagy."
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"Thus, TNFAIP3 inhibits mTOR signaling in this cell model."
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"On the other hand, A20-induced mTOR inhibition reduces the loss of mitochondrial membrane potential and the generation of Mitochondrial ROS."
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"TNFAIP3 promotes autophagy by inhibiting mTOR signaling in inflammatory human NPCs."
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"These findings revealed the relationship between degeneration process, inflammatory response, and autophagy in human NPCs, in which TNFAIP3 inhibits the mTOR signaling to ameliorate IVDD."
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"TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy."
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"TNFAIP3 inhibits mTOR signaling in the inflammatory human NPCs."
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"On the one hand, A20-induced mTOR inhibition triggers BNIP3-mediated mitophagy to ensure mitochondrial fitness under LPS stimulation, as a result of mitigating mitochondrial dysfunction induced by LPS."
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"Yu Matsuzawa et al. also found that TNFAIP3 promoted the survival of CD4 T cells by restricting mTOR and promoting autophagy [XREF_BIBR]."
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"Taken together, our findings illustrate that TNFAIP3 restricts MTOR signaling and promotes autophagy, providing new insight into the manner in which MTOR and autophagy regulate survival in CD4 T cells."
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"A recent study has identified that TNF-alpha-induced protein 3 (TNFAIP3) restricts mTOR activity and promotes macroautophagy and survival in CD4 + T-cells [XREF_BIBR]."
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