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USP2 inhibits LDL. 2 / 2

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"Since overexpression of Usp2 promotes the deubiquitination of IDOL, USP2 was considered to suppress LDL uptake via ubiquitin-dependent degradation of LDL [212]."

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"Transfection of a Usp2-expressing construct restored IDOL-repressed LDL uptake in cultured cells, whereas Usp2 knockdown reduced LDL uptake by ~50% in HepG2 hepatocytes [212]."

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IndraLab

Statements

USP2 inhibits LDL. 2 / 2

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