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PTEN inhibits MTOR. 229 / 245
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"In contrast, complete deletion of PTEN, which therefore activated the AKT/mTOR pathways and resulted in a 30% increase in protein synthesis, also abolished HSC functions."
32098201
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"The present study showed that overexpression and knockdown of PTEN led to inactivation and activation of mTOR and GSK-3beta, respectively, and overrode the effect of miR-19a on axonal outgrowth."
23595747
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"Because Pten deletion promoted mTOR signaling and axon growth rostral to injury irrespective of age in both the rubrospinal and corticospinal systems, we hypothesized that differences in environmental influences at and around the lesion site could be responsible for the age dependent decline in axon regeneration beyond the injury site."
27050519
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"Transfection of PTEN into the PC3 cells decreased the activation of Akt and the downstream mTOR regulated 70-kDa S6 (p70 (s6k)) kinase and reversed the resistance to doxorubicin in these cells, indicating that changes in PTEN status and Akt activation modulate the cellular response to doxorubicin."
12414639
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"XREF_BIBR PTEN is a negative regulator of PI3K and inhibits Akt and mTOR and MAPK signaling, leading to inhibition of cell growth and cell death."
25767376
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"MTOR signaling is positively regulated by IGFR and Akt, and negatively regulated by AMPK and PTEN."
20142804
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"Neuronal PTEN deletion is known to promote corticospinal tract (CST) axon regeneration after spinal cord injury via activating the mTOR pathway (Liu et al., 2010)."
36339257
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"A mechanistic study further reveals that downregulation of hepatic Me1 expression is largely mediated by the phosphatase and tensin homologue (PTEN)-dependent suppression of the mechanistic target of rapamycin/sterol regulatory element-binding protein 1 (mTOR/SREBP1) signaling pathway in hepatic I/R model."
36840630
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"We therefore decided to compare the primary effects of altered mTOR signaling on synaptic transmission in both glutamatergic and GABAergic neurons by characterizing autaptic cultures of neurons in which mTOR activity was increased by loss of the negative regulator Pten or decreased by treatment with the mTOR inhibitor rapamycin."
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"PTEN, another tumor suppressor, inhibits mTOR through inactivation of AKT [ xref ]."
24387336
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"Recently, mTOR activation by Pten or Tsc1 knockout was shown to promote the regenerative capacity of injured axons XREF_BIBR."
20062052
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"Loss of PTEN expression usually results in activation of AKT and mTOR pathway due to its antagonizing function to the PI3K/AKT/mTOR pathway, and activation of PI3K/AKT/mTOR pathway has been reported in human SGTs [XREF_BIBR]."
25909167
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"As PTEN blocks mTOR signaling ( Carracedo and Pandolfi 2008 ) , restraining cell proliferation , p53 , APC , and PTEN suppression may underlie pro-growth potentials of GH ."
37066857
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"PI3K-AKT and mTOR pathway is downregulated by PTEN, a tumor suppressor."
| PMC
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"Interestingly, RNAi mediated knockdown of EZH2 restored PTEN expression and down-regulated the AKT and mTOR activities in Evi1 transduced BM cells, suggesting that Evi1 functions as a platform to recruit PcG proteins to the PTEN locus."
21795762
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"PTEN deletion in young animals prevents axotomy induced reduction of mTOR activity and promotes the regeneration of retinal ganglion and CST axons after injury [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
27818358
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"Phosphatase and tensin homolog (PTEN) activation inhibits AKT and mTOR signaling, and current studies have confirmed that microRNA (miRNA) -21 targets PTEN to activate the AKT and mTOR pathway, which plays an important role in the key pathological damage observed in DN [XREF_BIBR, XREF_BIBR]."
25689721
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"To assess whether PTEN deletion elevates neuronal mTOR activity, we injected AAV-Cre into the sensorimotor cortex of PTEN f/f mice at P1 and examined the p-S6 signal in the adult."
20694004
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"MTOR hyperactivation by itself, however, does not appear to be sufficient to produce robust mossy fiber sprouting, as demonstrated by the absence of sprouting in some animals with enhanced mTOR signaling induced by PTEN loss."
29774009
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"MTOR is negatively regulated by the tumor suppressor PTEN, which is mutated or down-regulated in many cancers, including ccRCC."
24656772
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"Deletion of PTEN results in activation of Akt, TSC and mTOR and S6K signaling activation that results in feedback inhibition of IRS and Akt signaling [XREF_BIBR - XREF_BIBR]."
19541499
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"PTEN and SOCS3 deletions as well as the growth factors ' (OPN, IGF1 and CNTF) overexpression activate mTOR signaling (XREF_FIG a)."
32295297
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"In the second study, targeted miR-17-92 expression to B cells (miR-17-92 Tg/Tg; CD19 Cre) also induced B-cell lymphoma development, followed by PTEN down-regulation and enhancement of the mTOR pathway, altogether, showing a potent oncogenic role for miR-17-92 per se."
26442266
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"The expression of these receptors is also controlled by mTOR signaling, which is also triggered by PTEN loss."
19808258
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"A previous study reported that PTEN activation inhibits AKT and mTOR signaling in DN pathological injury [XREF_BIBR, XREF_BIBR]."
31668144
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"Moreover, genetic deletion of PTEN increases mTOR activation and results in substantial axon growth after injury."
27073365
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"Phosphatase and tensin homolog (PTEN) mutation in glioblastoma multiforme (GBM) patients causes abnormally high activity of the pathways of Phosphatidylinositide 3-kinases (PI3K), Protein Kinase B (AKT), and the mammalian target of rapamycin (mTOR) and is associated with unfavorable prognosis."
23564811
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"PTEN inhibition activates mTOR."
29451218
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"Experiments to identify miR-21 targets have shown that PTEN is downregulated, suggesting an activation of mTOR and the oncogenic properties of miR-21 in TNBC, with increased proliferation and invasion by TNBC cells."
30363988
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"Finally, as expected, many of these FluoroGold labeled RGCs also expressed DCX (XREF_SUPPLEMENTARY), a young-neuron marker up-regulated by Sox11 alone (XREF_FIG) and phospho-S6 (XREF_SUPPLEMENTARY), an mTOR activity indicator up-regulated by PTEN deletion."
28641110
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"MTOR stimulates protein translation initiation and is negatively regulated by another protein, phosphatase and tensin homolog (PTEN)."
22981450
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"These results indicated that removal of PTEN inhibition activated the mTOR pathway and generated more lactate."
29916308
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"While the prevalence of autophagy defects in HCC is not yet known, mutations such as pten loss that constitutively activates the PI3-kinase pathway and mTOR that inhibits autophagy are common."
19524509
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"The deletion of PTEN promotes mTOR hyperactivation in dentate granule cells of the hippocampus in a mouse seizure model."
29751355
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"Although we previously showed that PTEN loss can upregulate the mTOR/c-Myc axis in pNETs and that c-Myc activation may upregulate VEGFC to promote lymphangiogenesis in pNETs [9, 18]."
36336681
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"Our in vitro studies demonstrated that PTEN (phosphatase and tensin homolog) overexpression deactivated mTOR activity and induced 661W cone cell apoptosis."
30442943
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"Specifically, genomic profiling based on clinical-grade NGS could identify whether PTEN loss or other GAs activating the mTOR pathway are present alongside the BRAF fusion in a pilocytic astrocytoma of patient, thus suggesting a potential responsiveness to combined sorafenib and mTOR targeted therapy."
24422672
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"The most important function of PTEN is to inactivate the Akt/mTOR signaling pathway via conversion of PIP3 back to PIP2 [ 44 ]."
29710470
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"Inactivation of phosphatase and tensin homolog is associated with deregulation of the PI3K and Akt pathway and increased mammalian target of rapamycin signaling."
26612480
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"In adults mTOR is inactivated by phosphatase and tensin homolog (PTEN) and an emerging hypothesis proposes that the CNS does not regenerate in adults because of mTOR inactivation [ xref ]."
32806510
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"Thus, AAV infects, and PTEN restricts mTOR signaling in, most if not all RGC subtypes."
25754821
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"On the other hand, the natural inhibitor of PI3K/Akt, the enzyme PTEN (tumor suppressor phosphatase and tensin homolog), reduces the activity of this pathway by interfering with PI3K and negatively affecting mTOR signals."
31689909
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"Our findings suggest that PTEN gene copy number loss, which is highly prevalent in HNSCC, may result in sustained PI3K and mTOR signaling independent of EGFR, thereby representing a promising mechanistic biomarker predictive of cetuximab resistance in this cancer type."
32430488
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"Here we demonstrate that mTOR activity in Ehrlich Lettre ascites (ELA) cells is transiently increased within minutes following osmotic cell swelling and that inhibition of phosphatidylinositol-3-phosphatase (PTEN) counteracts the upstream phosphatidylinositol kinase and potentiates mTOR activity."
24696147
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"16 Although PI3K/AKT/mTOR is not a downstream molecule of PTEN, loss of PTEN activity has been reported to enhance the activity of AKT and mTOR, and the activation of these molecules may be involved in reducing the killing effect of gefitinib on tumor cells."
32956565
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"PTEN constrains the intrinsic regenerative capacity of the nervous system, and inhibition of PTEN expression enhances optic nerve regeneration and increases mTOR activity."
32629985
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"PTEN loss and subsequent activation of the PI3K and Akt signaling promotes the activation of mTOR signaling, which is hyperactive in many cancers (Carracedo and Pandolfi, 2008)."
28306514
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"Importantly, loss of PTEN results in increased AKT and mTOR signaling, suggesting that alterations in the mTOR and AKT pathways could also be therapeutically targeted in patients harboring PTEN loss."
25809148
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"Since PTEN negatively regulates the mTOR signaling pathway, we then investigated whether there was interaction between the MTOR rs2295080 and PTEN rs701848 in influencing RCC risk, however, as shown in XREF_TABLE, no significant interaction was observed (P interaction = 0.118), although individuals with both risk genotypes (rs2295080 TT and rs701848 CC) had a significantly increased RCC risk of 1.72."
23209702
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"PTEN in turn downregulates mTOR and induces autophagy, which may alleviate metabolic impairment caused by abrogation of ribosome biogenesis."
23764776
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"PTEN and other targets are downregulated, resulting in constitutive activation of Akt and mTOR (Enomoto et al., 1991; Okuda et al., 2010)."
35264951
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"The regulation of HSCs and leukemic cells might be governed by cell-context-dependent, PTEN mediated inhibition of mTOR [XREF_BIBR]."
19115995
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"Importantly, chronic stimulation shifts the equilibrium of the mTOR repressor PTEN to the inactive phosphorylated form suggesting a molecular transition to an axon growth state."
29729248
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"Thus, PI3K and mTOR signalling, which are negatively regulated by PTEN, are strikingly upregulated as a consequence of deleting Pten in the retina."
22403711
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"Recent studies have reported that the deletion or inhibition of PTEN can activate the mTOR signaling, thereby exerting neuroprotective effects following nervous system injury [XREF_BIBR - XREF_BIBR]."
33820561
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"Loss of PTEN, which is a tumor-suppressor gene that inhibits the PI3K/AKT/mTOR pathway, causes the aberrant mTOR pathway activation."
23468988
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"Indeed, deletion or inhibition of PTEN phosphatase elevates PI3K and mTOR signaling and causes rapid death of B-ALL cells."
28566433
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"Moreover, YAP has been shown to inhibit phosphatase and tensin homolog (PTEN), which itself normally inhibits the mTOR/Pi3K pathway (18)."
34671628
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"This indicated that loss of Pten activates Akt and that there might be a complex mechanism, through which Pten regulates the expression of Sox2 at different stages during ESCs differentiation.Mouse ESCs are maintained by using the cytokine LIF to activate Stat3 signaling , and PTEN negatively regulates PI3K/mammalian target of rapamycin (mTOR) , which promotes STAT3 activity ."
32034125
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"Moreover, mutations in the PTEN gene that indirectly repress the mTOR pathway are responsible for spectrum phenotypes including ASD with macrocephaly."
30627967
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"Since PTEN and p53 are well-known inhibitors of mTOR, the increased membrane area and folding in mutant GBM lines may be related to the enhanced protein and lipid synthesis due to a deregulation of the mTOR dependent downstream signaling pathway."
24498019
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"The Akt and mTOR pathway regulates many energy-expensive processes and is inhibited in quiescence and hibernation by the action of PTEN and TSC1/2 coupled with downstream RPP signaling."
33867999
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"PTEN, a dual-specificity phosphatase and tumor suppressor gene, inhibits Akt and mTOR and MAPK signaling pathways, leading to cell death and growth regulation."
26300629
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"Similarly in our study, knockdown of the PTEN not only restrained the levels of autophagy related protein to increase the viability, but also activate the AKT and MTOR pathway in NMDA treated RGCs."
29421576
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"Indeed, PTEN loss is known to activate PI3K and mTOR pathway and it has recently been shown that SPOP mut can do the same."
30333152
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"27 These findings suggested that downregulation of TET1 reduces the expression of PTEN, which subsequently activate AKT and MTOR pathway in COX-2-driven HCC."
28346420
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"In this study, we demonstrated that PTEN overexpression in 661W cone cells deactivated mTOR and its downstream target S6K1 activity and induced the 661W cone cell apoptosis in vitro."
30442943
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"We have previously shown that mTORC1 activity, detected as phosphorylation of 4E‐BP1, is transiently increased in mouse fibroblasts following hypoosmotic exposure, that is, mTOR activity is significantly increased and boosted by PTEN inhibition within minutes following osmotic cell swelling but reduced following prolonged (4 h/24 h) hypotonic adaptation (Lambert et al. 2014)."
30318853
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"PTEN could negatively regulate mTOR signal pathway and inhibit its activity."
20673489
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"Up to 70% of endometrioid endometrial cancers carry PTEN gene deletions that can upregulate mTOR activity."
24316308
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"In addition to FXS and RTT, a number of genetic susceptibilities have been linked to elevated autism risk including maternal 15q11-13 chromosomal duplications, anomalies in the tumor suppressor genes NF1, TSC1 and TSC2, and PTEN that activate mammalian target of rapamycin (mTOR)/phosphatidylinositol 3-kinase (PI3K) signaling pathways, and mutations in a range of synaptic genes such as the neurexins, neuroligins, SHANK3 and CNTNAP2."
21423490
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"In addition, PTEN over-expression or Akt inhibition suppressed mTOR activity, thereby increasing LC3-2 expression in IPF fibroblasts."
24728102
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"PTEN can inhibit Akt and mTOR signaling [XREF_BIBR]."
27863407
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"In adults mTOR is inactivated by phosphatase and tensin homolog (PTEN) and an emerging hypothesis proposes that the CNS does not regenerate in adults because of mTOR inactivation [156]."
32806510
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"PTEN, a well-known tumor suppressor that is competitively regulated by GAS5 in the subpathway region, inhibits the cancer related IGF-1 and mTOR pathway."
28152521
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"While PTEN inhibits the activation of AKT and thus mTOR, LKB1 phosphorylates AMPK which activates TSC to inhibit mTOR signaling."
29152604
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"Moreover, PTEN deletion in hippocampal dentate granule cells leads to mTOR hyper activation and promotes the rapid onset of spontaneous seizures."
28824380
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"XREF_BIBR PTEN inhibits Akt and mTOR and MAPK signaling, leading to cell death and growth regulation."
25792811
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"The over-expression of miRNA-21 decreases PTEN expression and simultaneously activates the Akt and mTOR signaling pathway, thereby inducing mesangial cell hypertrophy and mesangial matrix expansion."
25689721
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"Our results thus indicate that Pten deletion induces an mTOR mediated tumor suppressor response in hematopoietic cells, suppressing leukemogenesis and depleting HSCs."
21040901
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"XREF_BIBR PTEN, a dual-specificity phosphatase and tumor suppressor gene, inhibits Akt and mTOR and MAPK signaling, leading to cell death."
25609923
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"Our results are consistent with published data using mice harboring a deletion of Pten, a tumor suppressor gene that negatively regulates the Akt and mTOR pathway, since liver specific inactivation of Pten leads to steatosis and, eventually, HCC development."
21147110
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"Such studies suggest that the loss of PTEN in fact is not always sufficient to activate mTOR."
18759130
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"Our work and the work of others have previously shown that disruption of PTEN results in activation of mTOR signaling [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
27285754
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"7 EGFR, which belongs to the erbB family, activates the same downstream signaling pathways, including the Ras-Raf-MAPK signaling pathway and the phosphoinositide-3-kinase (PI3K)/AKT signaling pathway, involving other key effectors such as nuclear factor-kappaB and mammalian target of rapamycin (mTOR), which could be inhibited by phosphatase and tensin homolog (PTEN)."
33121309
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"PTEN antagonizes PI3K function, and the loss of PTEN activates the Akt and mTOR pathway."
26502919
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"Deletion of phosphatase and tensin homolog ( Pten ) augments mTOR signaling and enhances the intrinsic regenerative response of injured corticospinal neurons after SCI."
34759029
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"EZH2 recruited H3K27me3 to the promoter of PTEN and inhibited PTEN expression, and then activated the AKT and mTOR signalling pathway."
32814835
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"Previous studies have shown that PTEN deletion up-regulate mTOR activity and promote axon regeneration in retinal ganglion cells and corticospinal neurons ."
30442943
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"Pten and Lkb1 have been revealed as potent tumor suppressors of endometrial cancer in experimental mouse models, both of which also converge on and negatively regulate mTOR signaling."
24322983
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"These results suggest that loss of PTEN and activation of NTRK2 cooperate to increase these two signaling pathways, PI3K and mTOR and JAK-STAT3, known to be critical for the transformation of leukocytes [XREF_BIBR]."
27672444
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"The PTEN loss of function, which may result, in particular, from the reviewed genomic abnormality, has been shown to cause an upregulation of the AKT and mTOR pathway, primarily via activation of the kinase AKT1 [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29671777
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"The PTEN and TSC2 tumor suppressors function to antagonize mTOR (mammalian target of rapamycin) activation by Akt; hence, compound heterozygous inactivation of Pten and Tsc2 in the mouse may in principle exacerbate the tumor phenotypes observed in the single mutants in a reciprocal manner."
16027168
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"In fact, CD11c specific deletion of phosphatase and tensin homolog (PTEN), an Akt inhibitor that blocks the PI3K and mTOR pathway, expands the cDCs and pDCs [XREF_BIBR]."
33810248
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"Loss of PTEN in NSCLC drives the hyperactivation of PI3K/Akt and downstream mTOR, thus regulating multiple cellular functions."
32528035
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"We next investigated whether PTEN activation could enhance sensitivityto PI3K and mTOR inhibition."
30654190
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"We found that GSCs were highly sensitive to proteasome inhibition due to an underlying dependency on an increased protein synthesis rate, and loss of autophagy, associated with PTEN loss and activation of the PI3K and mTOR pathway."
33428749
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"PTEN deletion activates the PI3K and mTOR (mammalian target of rapamycin) pathway, which controls cell growth and size by regulating capdependent protein translation initiation."
18988856
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"We show that in KRAS-driven murine PDAC cells, loss of Pten strongly enhances both mTOR signaling and macropinocytosis."
32101748
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"MiR-101-3p overexpression promoted PTEN, inhibited PI3K, AKT and mTOR protein levels, as well as triggered the activation of AKT and mTOR."
33072314
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"Conditional deletion of PTEN in adult RGC markedly promotes mTOR activation, leading to increased neurons survival and robust axons regeneration after ONI XREF_BIBR XREF_BIBR."
27886260
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"A protein positioned downstream of PTEN, namely, PRAS40, does not inhibit the mTOR pathway in its phosphorylated form (discussed in Section 2.1), and it can therefore be assumed that upon activation of the mTOR pathway, these proteins are linked and correlate in terms of phosphorylation status."
22530122
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"On the other hand, the tumor suppressor phosphatase and tensin homolog (PTEN) negatively regulates PI3K [XREF_BIBR] and therefore suppresses mTOR activity."
24768033
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"Phosphatase and tensin homolog (PTEN) is also involved in the regulation of mTOR activity and usually inhibits mTOR via the inhibition of Akt [XREF_BIBR]."
30075746
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"The correlation between PTEN loss and activation of mTOR signaling is well documented by our group and others [XREF_BIBR, XREF_BIBR - XREF_BIBR]; however, concurrent inactivation of PTEN protein and upregulation of clock genes, such as BMAL1, is a novel discovery."
27285754
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"The same group revealed that concurrent activation of mTOR and Janus kinase and signal transducers and activators of transcription (JAK and STAT3) pathways, by double inhibition of PTEN and suppressor of cytokine signaling 3 (SOCS3), are necessary for sustaining long distance axon regeneration in the adult CNS."
28485030
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"MTOR activates the pro survival phosphoinositide 3 kinase-AKT kinase pathway and enhances somatic and axonal protein synthesis, while PTEN antagonizes mTOR signaling."
31535635
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"Interestingly, it has been shown recently that loss of Pten induces ER UDPase ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), and activation of the AKT and mTOR pathway leads to induction of pyruvate kinase isoenzyme type M2 (PKM2), which contribute to aerobic glycolysis, also known as the Warburg effect, and tumor growth in a xenograft model of prostate cancer."
25176644
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"It has been reported that ERbeta can regulate mTOR activation via multiple mechanisms, such as increasing PTEN expression and decreasing phosphorylation of AKT [XREF_BIBR, XREF_BIBR]."
27863380
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"Mester et al. found that the increase in PTEN expression inhibited the Akt and mTOR signaling pathway, leading to cell death and growth regulation 40."
28900281
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"This pathway includes several established proto-oncogenes (PI3K, AKT1) and tumor suppressor genes (PTEN - which reduces mTOR activity through inhibition of PI3K and AKT1 - TSC1, TSC2)."
21373201
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"The phosphatase and tension protein homolog (PTEN) is also known to downregulate mTOR pathway via both PI3K and AKT."
29934975
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"The exposure of CD4+ T cells to PD-L1 coated microbeads has been shown to result in an increase in expression of the phosphatase PTEN, which antagonizes PI3-kinase and mTOR function by facilitating the degradation of PIP 3."
22556133
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"Increased mTOR activity has been shown to enhance regeneration of injured axons by increasing neuronal protein synthesis, while PTEN signaling can block mTOR activity to attenuate protein synthesis."
34326064
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"Kaempferol Protects Against Cadmium Chloride Induced Memory Loss and Hippocampal Apoptosis by Increased Intracellular Glutathione Stores and Activation of PTEN and AMPK Induced Inhibition of Akt and mTOR Signaling."
31768814
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"In mouse endometrial and bladder cancers, loss of PTEN and LKB1 leads to activation of the AKT and mTOR pathway and results in tumors sensitivity to PI3K and mTOR inhibition."
29228674
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"Thus, aging does not appear to influence the extent of mTOR activation induced by Pten deletion, at least as assessed with p-S6 immunoreactivity and neuronal soma size."
27050519
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"PTEN and LKB1 loss synergistically enhances the activation of AKT and mTOR pathway, promotes the proliferation of pNET cell lines and confers the attenuated sensitivity of pNET cells to mTOR inhibitors."
29228674
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"Downregulation of TET1 therefore may activate AKT and mTOR pathways that are suppressed by PTEN."
28346420
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"PTEN has been shown to negatively regulate mTOR to induce autophagy in a variety of cell types XREF_BIBR, XREF_BIBR, and is activated by ATM in response to DNA damage to induce autophagy 33."
27935061
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"As expected, the loss of both Lkb1 and Pten in these tumors activated the AKT and mTOR pathways, likely driving cellular proliferation and tumorigenesis."
24794706
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"In a mouse model of bladder cancer, Shorning et al. demonstrated that loss of LKB1 (upstream kinase of AMPKalpha) and PTEN synergizes to activate AMPK and mTOR and that rapamycin treatment reduced tumor burden in mice XREF_BIBR."
27916296
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"MTOR can be inhibited by rapamycin via interaction with its receptor FK506-binding protein 12, and is activated by PI3K and PTEN loss; eventually this initiates carcinogenesis and subsequent progression via the oxygen and nutrient supply through the upregulation of HIF1α expression and promotion of angiogenesis (63,64)."
34779504
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"Patients with this germline variant are more likely to acquire somatic mutations in PTEN, a tumor suppressor gene, which suppresses mTOR signaling activity (Figure 1F) [11]."
33203571
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"The PTEN protein antagonizes PI3K function and negatively regulates Akt and mTOR activity [XREF_BIBR **]."
23396869
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"PTEN, which is a frequently mutated tumor suppressor in human cancers, also suppresses MTOR activity, subsequently activating autophagy [75, 76]."
31707087
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"More specifically, upregulation of miRNA-21 decreases PTEN expression, causing increased activity of AKT and the mTOR kinase pathways."
33540837
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"Tumors were assessed for immunohistochemical evidence of PTEN loss of expression and mTOR activation."
21301319
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"We therefore performed an electrophysiological and morphological comparison of glutamatergic and GABAergic neurons in which mTOR signaling was either increased by loss of the repressor Pten or decreased by treatment with rapamycin."
22895726
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"Consistent with these previous reports, our in vitro data from 661W cone cells confirmed that PTEN activity downregulated the mTOR pathway and induced 661W cone cell apoptosis, indicating the important role of the mTOR signaling in 661W cone cell survival."
30442943
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"Although axon regeneration and functional recovery from CNS injuries are typically limited, knockdown or deletion of PTEN, a negative regulator of mTOR, increases mTOR activity and induces robust axon growth and regeneration."
28626016
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"The PTEN phosphatase controls the levels of PIP 3 induced by growth factor activation of PI3 kinase, and acts to negatively regulate mTOR activity."
18728656
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"However, Magee et al. elegantly demonstrated that after PTEN deletion, which activates the mTOR-signalling pathway, deletion of Rictor abrogates leukaemogenesis and HSC depletion in adult, but not neonatal, mice [53], highlighting that the PTEN-mTORC2 signalling axis has a role in activating these processes in a temporally dependent manner."
30154096
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"As it is central to multiple tumorigenic pathways, downregulation of mTOR pathway inhibitors such as PTEN and TSC2 was a highly significant finding (~ 85%) in a gene expression profiling of PNETs, even in the absence of a pathway specific mutation."
33537001
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"Low PTEN expression after nerve injury promotes Akt and mammalian target of rapamycin (mTOR) signaling pathway activity."
29649487
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"The downstream mechanisms whereby PTEN deletion promotes axonal regrowth are well characterized : PTEN deletion activates the PI3K and mTOR (mammalian target of rapamycin) pathway, which controls cell[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
23211458
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"42,43 Phosphatase and tensin homolog (PTEN) negatively regulates mTOR signaling through down-regulation of Akt function, and mTOR thus constitutively is hyperactivated in Pten null MEFs."
25980751
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"We found that PR-957 upregulated PTEN protein expression and inhibited AKT/mTOR signaling in the Ang II–infused heart; these changes in signaling pathway were reversed by VO-OHpic (Figure 5B)."
32595507
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"44 In contrast, PTEN dependent downregulation of mTOR signaling and subsequent activation of autophagy might be pro survival responses that enable MSNs to survive for a certain time in stress conditions."
23764776
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"There is an accumulating evidence to indicate that genetic loss of PTEN in cell lines and animal will lead to activation of Akt and mTOR XREF_BIBR, XREF_BIBR."
24124460
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"Mutated or down-regulated in many advanced cancers [XREF_BIBR], PTEN loss activates the PI3K-AKT [XREF_BIBR] signaling pathway and its downstream target mTOR, with important implications in RCC development and therapeutic selection [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
20420713
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"Since PTEN phosphatase activity prevents mTOR (mammalian target of rapamycin) by inhibiting PI3K and Akt pathway, restoration of mTOR activity was found to promote axon regeneration in mice [XREF_BIBR]."
31530116
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"PTEN, another tumor suppressor, inhibits mTOR through inactivation of AKT [XREF_BIBR]."
24387336
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"Conjunctiva melanomas displayed high expression of phospho-mTOR effectors in contrast with uvea melanomas, in which PTEN seemed to downregulate the mTOR pathway."
20173664
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"Loss of PTEN and consequent elevation of AKT activity can promote both mTOR as well as AR dependent proliferation."
22614157
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"Similar effects of ezetimibe have been noted in other tumor bearing models if mice are fed a low-fat, low-cholesterol diet.30 Although PTEN deficiency can increase cholesterol synthesis by activating the mammalian target of rapamycin and its downstream targets PPAR-gamma, srebp-1 and srebp-2,31 the increase in serum cholesterol levels was mild in Pten Deltahep mice."
30520543
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"Despite clear association between PTEN loss-mediated overactivation of AKT/mTOR signaling and aberrant neuronal form and function, the precise downstream molecular mechanisms resulting in these varied phenotypes are not well delineated."
36323257
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"Here, we show that EpCAM overexpression inhibits PTEN expression and activates AKT and mTOR signalling in NPC cells."
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"PTEN upregulation—with consequent inhibition of mTOR and PD-L1—has been documented in mice injected with PC-cells overexpressing chemerin (PTEN activator)."
| PMC
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"PTEN also negatively regulates mTOR by turning off PI3K-AKT signaling."
25446259
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"PTEN loss and subsequent activation of the PI3K and Akt signaling promotes the activation of mTOR signaling, which is hyperactive in many cancers."
28306514
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"ROS signaling, often in the presence of hypoxia, activates PTEN which inhibits the PI3 kinase and mTOR pathway, thus promoting autophagic flux."
28491867
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"However, there is a concern that in Treg, which overexpress PD-1 in the TME, PDL-1 signaling up-regulates PTEN expression, blocks the Akt and mTOR pathway and activates STAT5 and STAT3 signaling, leading to expansion of Treg and promoting their suppressive functions."
27084738
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"In the noncanonical pathway, N interacts with PTEN induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling."
24352421
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"Importantly, miR-21 activates the Akt/mTOR pathway by silencing of PTEN to inhibit autophagy, leading to elevated MMP-3 and MMP-9 expression and subsequent Col II and aggrecan degradation in human deg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29710470
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"We and others have previously demonstrated PTEN loss and activation of the mTOR pathway in urothelial carcinoma [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
23084634
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"We tested the potential of eFT226, a sequence-selective inhibitor of eIF4A-mediated translation, in the treatment of mTOR hyperactive cells caused by the deletion of tuberous sclerosis complex 1/2 (TSC1/2) or phosphatase and TENsin homology (PTEN)."
35805935
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"PTEN loss activated the PI3K pathway but did not increase mTOR activity ."
34535684
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"PTEN is an important down-regulator of Akt and mTOR, a pathway that is involved in MTC tumorigenesis."
28929017
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"Heterozygous PTEN copy loss along with PTENW111* nonsense mutation in the initial tumor suggested a bi-allelic loss of PTEN function that likely induced mTOR signaling."
34635112
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"In our model the combined deletion of both Lkb1 and Pten in the mouse bladder drastically activates mTOR pathway and this precise activation serves as a signal for EMT program execution (XREF_FIG)."
21283818
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"Since PTEN inhibition was previously shown to activate mTOR and promote neuronal survival and axon regeneration, we thus examined whether a genetic knockout of c-myc might affect the axon regeneration induced by shRNA mediated PTEN silencing."
25937169
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"On the other side, PTEN deletion in these neurons could increase mTOR activity and promote their regrowth ability."
20694004
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"XREF_BIBR PTEN, a dual-specificity phosphatase and tumor suppressor gene, inhibits Akt and mTOR and MAPK signaling, leading to cell death and growth regulation."
25834399
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"The tumor-suppressor phosphatase PTEN negatively regulates the mTOR pathway ."
30442943
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"Conversely, PTEN, a multi-functional negative regulator of cellular signaling and genomic stability, is known to inhibit mTOR activation, perhaps through inactivation of AKT [XREF_BIBR]."
23375848
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"Also, patients with germinal mutations in phosphatase and tensin homolog (PTEN; a negative modulator of mTOR) have been observed in 11 out of 31 LDD patients and associated with granular cell hypertrophy."
27378854
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"Loss of PTEN also activates the mTOR pathway, causing senescence [XREF_BIBR]."
22246147
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"In addition, the PTEN gene can inhibit mTOR activity by negatively regulating the PI3K and Akt signaling pathway, therefore inhibiting cancer cell proliferation, promoting apoptosis and reversing multidrug resistance."
29163680
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"GH induced decreased PTEN may trigger mTOR activity, stimulating cell proliferation and survival, while p53 deficiency may also enhance proliferation, exacerbating GH effects on DNA damage accumulation."
31939481
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"Thus PTEN, by suppressing PI3K and Akt signaling, also suppresses the downstream mTOR kinase activity."
22572802
sparser
"Phosphatase and tensin homolog (PTEN) is also involved in the regulation of mTOR activity and usually inhibits mTOR via the inhibition of Akt [ xref ]."
30075746
reach
"The mTOR pathway can be activated by mutations in the PI3K, mTOR or AKT genes; loss of PTEN, NF-1, PIK3CA, VHL, TSC2, or TSC1; or constitutive activation of Ras, Src, Raf, or MEK [XREF_BIBR - XREF_BIBR]."
26756023
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"However, PTEN can inhibit Akt and mTOR signaling [XREF_BIBR]."
27391155
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"Previous literature has shown that PTEN inhibits the Akt/mTOR pathway in the functional recovery after SCI [29]."
34381025
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"While PTEN negatively regulates mTOR signaling, SOCS3 negatively regulates STAT3 signaling."
36339257
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"This was further observed alongside PTEN loss and overexpression of Akt and mTOR, suggesting activation of the PI3K/Akt/mTOR pathway in these tumours."
32725435
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"Mammalian target of rapamycin (mTOR) pathway is suppressed in adult central nervous system, reactivating the mTOR pathway by silencing PTEN in adult retinal ganglion cells can induce extensive axon regeneration (Park et al. 2008)."
34337686
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"Loss of PTEN leads to upregulation of mTOR signaling, and mTOR inhibitors have been used to treat multiple cancer types."
32325871
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"When either PTEN or TSC1 were silenced in order to reactivate the mTOR pathway, it led to induction of extensive axon regeneration in adult neurons."
22449213
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"3.3 Inhibition of PTEN promotes axon growth in IB4 + neurons independent of mTOR."
32744427
sparser
"One of the major signaling pathways playing a role in the onset and progression of this disease is PI3K/Akt/mTOR, which can be inhibited by PTEN."
30132256
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"The capacity for axonal regeneration declines with age in mice, and at least part of this decline is associated with an age related decline in the MTOR pathway driven by the negative MTOR regulator Pten."
33479258
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"Deleterious mutations or loss of PTEN, activates AKT/mTOR signaling and has been implicated in resistance to EGFR TKIs[11]."
33159216
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"Similarly, phosphorylation of the eukaryotic initiation factor 4E binding protein, a direct mTOR target, was reduced in TIF-IA D1RCre mice, supporting that upregulation of PTEN impairs mTOR function in MSNs (XREF_FIG)."
23764776
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"Another example is the tumor suppressor gene Pten, known to negatively regulate the activity of the PI3K and mTOR pathway, which is involved in various cancers [XREF_BIBR, XREF_BIBR]."
27049721
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"Because PTEN deficient myeloma cells may have up-regulated activity of the mammalian target of rapamycin (mTOR), downstream of AKT, they may be particularly sensitive to mTOR inhibition."
12208757
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"AMP activated protein kinase (AMPK) and phosphatase and tensin homolog (PTEN) signaling negatively regulate mTOR signaling to promote autophagy XREF_BIBR XREF_BIBR."
27251306
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"Pten deletion rescues axotomy induced mTOR downregulation and cell atrophy in both rubrospinal and corticospinal neurons regardless of age."
27050519
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"XREF_BIBR, XREF_BIBR This induces histone modifications (H3K27me3), which represses PTEN transcription and activates the PI3KAKT and mTOR signaling pathway."
22895111
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"Genetic Pten deletion in young animals prevents axotomy induced reduction of mTOR activity and promotes the regeneration of both retinal ganglion and corticospinal tract (CST) axons after CNS injury."
27050519
reach
"In an in vitro and in vivo experiment, the venom upregulated the expression of PTEN and BAX to inhibit the growth of subcutaneous H tumors in mice and downregulated PI3K, AKT and mTOR to inhibit tumor cell proliferation [44]."
31210759
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"PTEN deletion enhances mTOR signaling and increases dendritic aborization in cortical neurons [XREF_BIBR]."
29789464
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"Taken together, these findings suggest microRNA-221 suppresses PTEN transcription and activates Akt and mTOR pathway, which in turn enhances breast cancer resistance to adriamycin and promotes cancer development."
31899608
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"Lkb1 and Pten Synergise to Suppress mTOR Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder."
21283818
reach
"PI3K-Akt signaling is antagonized by PTEN, and loss of PTEN enhances mTOR activation."
25653651
reach
"MTOR is inhibited, in part, by two tumor-suppressor proteins, TSC2 and PTEN."
23391115
sparser
"MTOR is inhibited, in part, by two tumor-suppressor proteins, TSC2 and PTEN."
23391115
reach
"As a result, PTEN is upregulated to repress AKT and mTOR activity and then activates autophagy, sequentially reversing sorafenib resistance."
28981093
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"Deleting PTEN activates mTOR, which presumably leads to downstream changes in mRNA translation regulated by mTOR signaling."
26896833
reach
"HSCs lacking Pten, a phosphatase that inactivates PI3-K signaling and negatively regulates the mTOR pathway, also display increased cell cycle activity and impaired self-renewal capacity, with Pten deficient mice succumbing to leukemia XREF_BIBR, XREF_BIBR."
24067363
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"In addition, the combination of miR-370 and PTEN inactivated AKT, MDM2 and mTOR while stimulated caspase-3, p53 and GSK3beta expression, promoting apoptosis and suppressing proliferation of gastric cancer cells."
27499479
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"Loss of functional PTEN results in increased mTOR signaling and promotes cellular proliferation."
24077915
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"PTEN, NF1, and TSC1/2 are all inhibitors of mTOR so that their pathogenic mutations all have the downstream effect of increasing mTOR signaling."
24155705
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"PTEN loss or AKT3 activation, which both increase mTOR signaling, are also frequent events in nevus associated human melanoma."
26183406
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"The distinguished role of PTEN for neuronal cell survival was underlined in studies where a conditional deletion of PTEN or Tsc1 was used to increase mTOR activity in RGC after ON lesion."
22065949
reach
"Alternatively, it is possible that the effects on the PI3K and mTOR pathway mediated by PTEN loss are not reflected in steady-state levels of these various phosphorylated proteins or that PTEN loss results in effects on prostate cancer in addition to the PI3K and mTOR pathway (eg, c-Jun N-terminal kinase [JNK] signaling and/or enhancer of zeste homolog 2 [EZH2] overexpression)."
22674438
reach
"The physical microenvironment can be transformed into pathological tumours, fibrosis and inflammatory microenvironments, inducing age-related diseases, such as cancer, degenerative diseases and inflammation However, in a special type of senescence, PTEN loss-induced senescence (PICS), mammalian target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2) can directly stabilize p53 and initiate the p21-associated senescent pathway through PI3K/AKT activation and MDM2 inhibition without triggering the DDR (Jung et al., 2019) ."
34609061
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"In MDS and myeloid malignancies with EVI1 translocations, this transcription factor can cause PTEN repression and activation of PI3K and mTOR pathways [XREF_BIBR], thereby leading to increased cell proliferation and reduced differentiation."
23841999
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"PTEN loss and simultaneous activation of AKT and mTOR signaling is frequently observed in human ovarian carcinomas."
28819441
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"Our data suggest that UA inhibits miR-21 expression and increases PTEN expression, which in turn inhibits Akt and mTOR and restores normal levels of autophagy."
26567247
reach
"Deletion of Pten activates the PI3K and mTOR pathway, which controls cell growth and size by regulating cap dependent protein translation initiation."
27163547
reach
"Furthermore, p53 activates genes such as AMP activated protein kinase beta, tuberin and PTEN to suppress the mTOR (nutrient sensor) signaling pathway, which participates in aerobic glycolysis and oxidative phosphorylation."
33868474
reach
"Another frequent disregulation in RCC is the loss of PTEN, which stimulates mTOR through enhancement of the PI3K and Akt pathway."
20207176
reach
"Notably, forced expression of PTEN in GIST-T1R cells negatively regulated the Akt and mTOR pathways and sensitized these cells to sunitinib mediated growth arrest and apoptosis."
21445973
reach
"Mutations or deletions of phosphatase and tensin homolog (PTEN) and the heterodimeric complex of tuberous sclerosis proteins 1 and 2 (TSC1 and hamartin, TSC2 and tuberin) can dramatically upregulate mTOR signaling and contribute to a class of human neurological diseases characterized as " TORopathies "."
24672426
reach
"Reduction of PTEN activates the PI3K and mTOR signaling pathway."
23595747
reach
"To identify alternative mechanisms involved in Pten-regulated ESC maintenance, we assessed the activity of several signaling pathways, including the MAPK and mTOR pathways, and loss of Pten promoted the mTOR signaling pathway (Fig. S5d)."
32034125
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"Induction of the phosphatase PTEN was elevated in cells from IL37-tg [XREF_BIBR]; as discussed in [XREF_BIBR], PTEN inhibits the PK3 kinase, mTOR, MAPK and FADK pathways."
27060871
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"Additionally, activation of AMPK and PTEN could inhibit mTOR signaling, implying that pAMPK and PTEN function as tumor suppressors in the development of human cancer."
25909163
reach
"In addition, up-regulation of Ataxin-3 inhibited the expression of PTEN and activated the AKT and mTOR pathway."
29902454
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"XREF_BIBR These effects are mediated, at least in part, through LC3 and by p53 dependent activation of mTOR suppressors such as AMPK beta and PTEN, and require DRAM."
25593583
reach
"On one hand, our observation suggests that deletion of both Tgfbr1 and Pten will activate mTOR."
22859719
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"For example, a PTEN gene deletion, found in 16 to 32% of PCa, results in increased mTOR signaling, and increased mTOR signaling is correlated with poor survival in PCa [24]."
35225948
reach
"As PTEN blocks mTOR signaling (Carracedo and Pandolfi 2008), restraining cell proliferation, p53, APC, and PTEN suppression may underlie pro-growth potentials of GH."
37066857
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"PTEN targeting by microRNAs result in mTOR pathway activation and dysregulation of these microRNAs lead to an uncontrolled cell proliferation leading to cancer."
33614488
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"PTEN is well-known to negatively regulate Akt and mTOR pathway [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
26046303
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"PTEN loss or PI3K mutation have been shown to induce mTOR activation and mediate trastuzumab resistance [XREF_BIBR]."
25189767
reach
"PTEN promoter methylation correlates with decreased PTEN protein expression, which often increases AKT and mTOR pathway activation in tumor progression [XREF_BIBR]."
25762617