IndraLab

Statements


Phosphatase-active PTEN inhibits MAPK1. 2 / 2
2 |

"Modified assertion"

"overexpression of wild-type PTEN in the MCF-7 breast cancer line results in phosphatase activity-dependent decreases in the phosphorylation of ETS-2 PTEN blocks insulin-stimulated ETS-2 phosphorylation Our observations, therefore, suggest that PTEN blocks insulin-stimulated ETS-2 phosphorylation through inhibition of the ERK members of the MAP kinase family"