IndraLab

Statements

OTUB1 activates OTUB1. 3 / 4
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"Binding of free ubiquitin to the OTUB1 distal site leads to conformational changes in its OTU domain and the formation of a ubiquitin-binding helix in the structure spanning residues 25–44 in the OTUB[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, these findings indicate that PKP3 upregulates OTUB1 expression at the posttranscriptional level rather than at the transcriptional level, possibly by increasing the stability of OTUB1 mRNA."
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"These data suggest that SET7 and OTUB1 do not affect each other at protein level although they directly associate in cells.As reported previously, phosphorylation of OTUB1 at Serine 16 by Casein kinase 2 causes nuclear accumulation of OTUB1 (33), we sought to know whether SET7-mediated methylation of OTUB1 at K122 could alter subcellular localization of OTUB1."
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