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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BAP1 inhibits homologous recombination. 3 / 3

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"BAP1 is rapidly recruited to DSB sites, and BAP1 depletion leads to reduced BRCA1, RAD51 and RPA foci and has been suggested to decrease HR."

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"BAP1 loss specifically reduces HR but not NHEJ [68,69]."

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"As BAP1 loss causes deficient HR, BAP1-mutant tumors were reported to be particularly addicted to alternative DNA repair pathways, e.g., PARP1 mediated ones."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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Statements

BAP1 inhibits homologous recombination. 3 / 3

Our Sources:

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