IndraLab

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OSM activates LIFR. 26 / 30
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"For example, ERK1/2, PI3K, and STAT1/3 can be activated by OSM binding the LIFR or OSMR, but only signaling through the OSMR can activate STAT5, p38, JNK, and possibly PKC-δ and STAT622.OSM has been identified as a potential therapeutic target for treatment of inflammatory diseases."
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"In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective cognate ligands while OSM activates both the OSMR and LIFR in humans, which prevents efficient translation of mouse data into potential clinical applications."
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"In rats, human OSM activates the LIFR complex but not the OSMR complex, and murine OSM binds only the OSMR complex, whereas rOSM activates both type I and type II receptor complexes [ xref , xref ]."
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"gp130 and OSMR is activated only by OSM, but gp130 and LIFR can be activated by either LIF, OSM or both."
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"11 The receptor for OSM includes gp130 and a specific chain, OSMR; in human, but not in mouse, OSM also activates LIF receptor complexes."
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"Mouse OSM was thought to differ from human OSM in that it could signal only through a gp130:OSMR receptor complex because of its much higher affinity for OSM [24] , however mouse OSM was also recently[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, human OSM only activates gp130 and OSMRbeta and not LIFR in human adipocytes."
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"In rats, human OSM activates the LIFR complex but not the OSMR complex, and murine OSM binds only the OSMR complex, whereas rOSM activates both type I and type II receptor complexes [21,23]."
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"Additionally, OSM induced biological effects by activating functional receptor complexes of the common signal transducing component gp130 and OSMRβ or LIFR, which are mainly involved in chronic inflammatory and cardiovascular diseases, cancer and rheumatoid arthritis ."
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"Activation of the LIFR by OSM promotes bone growth and may also suppress breast cancer metastatic phenotypes [ xref , xref ]."
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"LIFR and gp130 can be activated by either LIF or OSM, but OSMR and gp130 is activated only by OSM [18]."
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"Mouse OSM, which has been used in the present study, is known to utilize the mouse OSMR, whereas human OSM utilizes the LIFR in mouse cells. xref , xref It has been found, however, that mouse OSM activates the mouse LIFR when decreasing Sost expression in mouse calvarial osteocytes. xref Furthermore, 172 identical genes are regulated by mouse OSM and LIF in osteoblasts fromOsmr −/- mice, which demonstrates that OSM can utilize the LIFR:gp130 complex to regulate several genes. xref We, therefore, silenced Il6st (encoding gp130), Lifr and Osmr and found that expression of Il6st and Osmr , but not that of Lifr , is important for efficient OSM induction of Wnt16 ."
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"OSM can activate OSMR- or LIFR-containing receptor complexes to engage downstream signaling."
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"OSM can signal though both the LIFR (OSMR type I in humans) and OSMR (OSMR type II in humans) in humans and rats, while in mice, only signaling via the OSMR is possible."
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"Mouse OSM generally does not activate LIFR, except at very high concentrations, where it can weakly stimulate LIFR."
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"There is a single report that mouse-derived OSM can activate LIFR specifically in mouse osteoblasts, suggesting a degree of context-dependent flexibility [ xref , xref , xref ]."
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"11 The receptor for OSM includes gp130 and a specific chain, OSMR; in human, but not in mouse, OSM also activates LIF receptor complexes."
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"53 As a member of the IL-6 family of cytokines, OSM has homogenous protein sequence and structure as that of other family members.57 Studies in the mouse showed that human OSM activates the heterodimer of LIF receptor B and gp130, as does CNTF.58 59 An increase in STAT3 phosphorylation was localized to Müller cells after intravitreal delivery of OSM in an ONC model, indicating that the neuroprotective effect of OSM on the RGC is medicated by Müller cells."
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"Only high concentrations of mouse-derived OSM can weakly activate LIFR, but there is also a single report that mouse-derived OSM can activate LIFR in mouse osteoblasts ( xref ) ( xref , xref , xref )."
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"Other ligands have been identified for mouse LIFR, including oncostatin M (encoded by Osm ) that activates specific LIFR-mediated signalling pathways to maintain bone mass ( Walker et al., 2016 ) and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The observed increase in bone volume in OSMR null mice might be due to the fact that OSM in this case only signals via LIFR and thereby acts on sclerostin [ 66 ]."
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"gp130 and LIFR can be activated by LIF or OSM, but gp130 and OSMR is activated by OSM only."
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"OSM activates both OSMR and LIFR in humans, while mice osm (mOSM) is generally capable of osmr binding only."
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"Mouse OSM, which has been used in the present study, is known to utilize the mouse OSMR, whereas human OSM utilizes the LIFR in mouse cells.55,56 It has been found, however, that mouse OSM activates the mouse LIFR when decreasing Sost expression in mouse calvarial osteocytes.31 Furthermore, 172 identical genes are regulated by mouse OSM and LIF in osteoblasts from Osmr mice, which demonstrates that OSM can utilize the LIFR:gp130 complex to regulate several genes."
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"In mouse cells, only mouse OSM is capable of activating the mouse OSM receptor; human OSM instead activates the LIF receptor."
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"In mouse cells, only mouse OSM is capable of activating the mouse OSM receptor; human OSM instead activates the LIF receptor."
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