IndraLab

Statements

USP3 deubiquitinates RIGI. 3 / 3
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ubibrowser
"<span class="match term0">USP3</span> inhibits type I interferon signaling by deubiquitinating <span class="match term1">RIG-I</span>-like receptors"
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"For example, TNFAIP3, CYLD, USP3, USP4, USP15, USP25, and OTUD5 deubiquitinate key components of the IFN production pathway, including RIG-I, TRAF2, TRAF3, TRAF6, RIP1, and TRIF (reviewed in [93,94])."
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"CYLD (cylindromatosis) deubiquitinates RIG-I and several downstream molecules to prevent premature RIG-I activation in uninfected cells [XREF_BIBR], while USP3 deubiquitinates RIG-I specifically after viral infection, likely serving as a negative feedback regulator [XREF_BIBR]."
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