IndraLab

Statements

CORM-2 inhibits KCNH2. 3 / 3
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"The ability of CORM-2 to inhibit recombinant hERG was blocked by the antioxidant ebselen (100 nM; XREF_FIG), which indicates the likely involvement of reactive oxygen species (ROS)."
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"Pretreatment of cells with FeTPPS (1 h at 37degreesC, 25 muM) also prevented the inhibition of hERG by CORM-2 (XREF_FIG)."
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"Pretreatment of cells with either antimycin A (XREF_FIG) or myxothiazol (XREF_FIG) -- both applied at 1 muM for 1 h at 37degreesC -- almost fully prevented the inhibition of hERG by CORM-2, which suggests that CO-mediated inhibition of hERG involves mitochondria derived ROS."
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