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USP2 deubiquitinates MFN2. 2 / 2
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"However, whether USP2 induces the deubiquitination of MFN2 to regulate cardiac hypertrophy has not been reported before and warrants further exploration.In light of the above associations, we raised a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP2 overexpression decreases the concentration of Ca and increases SERCA2a by deubiquitinating mitochondrial protein Mitofusin-2 (Mfn2), alleviating mitochondrial dysfunction, and apoptosis in the Ang II-induced cardiac hypertrophy mouse model [150]."
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