IndraLab

Statements

USP44 activates AXIN1. 3 / 3
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"We found that USP44 overexpression increased Axin1 protein while decreased beta-catenin, c-myc and Cyclin D1 proteins, suggesting that USP44 inhibited the activation of Wnt and beta-catenin pathway."
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"Another DUB, USP44, modulates Axin-1 protein by regulating β-catenin, c-Myc, and cyclin D1 in the Wnt/β-catenin pathway [128,129]."
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"The results showed that USP44 overexpression increased Axin1 protein while reducing β-catenin, c-myc and cyclin D1 protein, indicating that USP44 inhibited the activation of Wnt/β-catenin pathway mediated CRC cell apoptosis [41]."
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