IndraLab

Statements

BAP1 activates RAD51. 5 / 5
| 5
reach
"BAP1 can deubiquitylate Ub-H2AK119 at the site of UV-induced DNA damage, and promote DNA repair by regulating the accumulation of repair proteins (BRCA1, RAD51, and RPA) (7)."
32944533
reach
"BAP1 depletion abrogates the binding of INO80 to replication forks and increases the formation of RAD51 foci following HU treatment."
31657441
reach
"BAP1 also promotes the assembly of Rad51 foci to facilitate DNA repair and replication fork restart during replication stress ."
36754982
reach
"BAP1 depletion prevented RAD51 from binding to chromatin and forming replication foci after HU treatment."
37009801
reach
"Depletion of BAP1 leads to reduced BRCA1 foci, and reduced RAD51 loading, with reduced HR repair and increased IR sensitivity coinciding with elevated H2A and H2AX ubiquitylation."
38572758