IndraLab

Statements

Modified STAT3 increases the amount of COPS5. 6 / 6
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"Ectopic overexpression of Stat3 increased transcriptional activity as well as mRNA and protein levels of Jab1."
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"The present study yielded strong evidence that Stat3 overexpression mediates Jab1 overexpression in NPC oncogenesis."
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"Expression of exogenous wild type Stat3 increased Jab1 expression, whereas the dominant negative EEE/VV mutation reduced Jab1 protein levels."
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"Because Stat3 expression in NPC was associated with Jab1 expression, we sought to determine whether the overexpression of Stat3 could enhance Jab1 transcription in NPC cells."
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"Ectopic expression of Stat3 in CNE1, CNE2, and HONE1 NPC cells increased Jab1 expression (XREF_FIG and XREF_SUPPLEMENTARY)."
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"As Jab1 expression in normal mammary epithelial cells is low, we asked whether overexpression of Stat3 could enhance Jab1 transcription in these cells."
21689417