IndraLab

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"We found that de-conjugation of SUMO-2/3 led to de-repression, loss of promoter occupancy by CoREST1 and LSD1, increased H3K4 methylation, and increased H3 acetylation of the SCN1A and SCN3A genes, but did not affect another CoREST1 and LSD1 target gene, SCN2A2."