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KCNMA1 activates NS 1619. 18 / 18
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"As an internal positive control for the assay, we artificially raised the extracellular K concentration with K SO to 45 mM, which resulted in the expected Em depolarization.Second, we quantified the baseline and TNF-α-induced CCL-2 and IL-6 secretion from pulmonary endothelial cells after BK channel activation-mediated Em hyperpolarization with NS1619 (Figure 1E,F)."
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"Surprisingly, BK channel activator NS1619 (30muM) also increases the basal tension and amplitude in intact bladder strips."
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"From a pharmaco-genomic perspective, this is the first study to show that cardioprotection in the intact heart by the putative SLO1 activators NS1619 and NS11021 actually requires the Slo1 gene product (XREF_FIG and XREF_FIG)."
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"In addition, pretreatment with BK channel activator NS-1619 or blocker iberiotoxin and PKC inhibitor Bis1 did not affect H 2 O 2 -elicited increases of the basal tension and amplitude."
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"The human DSM single BK channel currents exhibited properties consistent with those reported for these channels in other systems : the mean single-channel conductance of more than 200 pS, P o highly dependent on the voltage and intracellular Ca 2+ concentration, enhancement of single-channel activity by the BK channel activator NS1619 and blockade by the selective BK channel inhibitor paxilline."
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"Leptin effects were mimicked by the synthetic BK channel activator NS1619 (1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl) phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one), and inhibited by the BK channel inhibitors, iberiotoxin and charybdotoxin."
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"They further demonstrated that mitochondrial uptake of K + was blunted by charybdotoxin and iberiotoxin and accelerated by the BK channel activator NS1619."
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"In pressurized, myogenic (60 mmHg) control arteries transfected with scrambled siRNA, the BK channel activator NS1619 stimulated a mean vasodilation of ~ 34.7 mum, and the specific BK channel inhibitor, iberiotoxin, produced a mean constriction of ~ 25.5 mum (XREF_FIG)."
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"Application of the selective BK channel activator NS-1619 (1 muM; Oelsen et al., 1994) also mimicked the actions of insulin, causing 50 +/-6.4% inhibition of the oscillatory activity (n = 31 cells / n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The ATP activated K+ current was inhibited by iberiotoxin (200 nM), and it was potentiated by the BK channel activator NS-1619 (30 microM)."
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"Similarly, addition of the selective BK channel activator NS-1619 inhibited the spontaneous Ca 2+ oscillations in a readily reversible manner."
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"To explore the role of BK channels in regulation of apoptosis in human ovarian cancer cells, the effects of the specific BK channel activator NS1619 on induction of apoptosis in A2780 cells were observed."
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"The ability of leptin to modulate this activity requires activation of BK, but not K (ATP), channels as the effects of leptin were mimicked by the BK channel activator NS-1619, and inhibited by the BK channel inhibitors, iberiotoxin and charybdotoxin."
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"As a complementary approach we then examined the efficacy of a specific BK channel activator NS1619 in restoring the precision of pacemaking."
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"The relaxation to BK channel activator NS1619 was attenuated in the coronary artery with adenovirus transfected MuRF1."
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"Neither the BK channel blocker iberiotoxin (100nM) nor the BK channel activator NS-1619 (30muM) affected the H 2 O 2 -induced augmentation of spontaneous contractions (XREF_FIG, XREF_TABLE)."
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"Both native and recombinant BK channel activities are enhanced by the BK channel activator NS1619 and inhibited by the selective blocker paxilline [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Thus, the primary effect of the BK channel activator NS1619 was to increase the P o or channel gating."
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